Results 11 to 20 of about 6,242 (173)
MutYH-associated polyposis [PDF]
Terapevticheskii arkhiv, 2019 MutYH-associated polyposis is the only polyposis syndrome with an autosomal recessive type of inheritance, often phenotypically similar to a weakened form of familial adenomatous polyposis. For the development of the disease mutations in both alleles of the gene are required, but an increased risk of developing colorectal cancer in carriers of ...
M Kh Toboeva +4 more
openaire +3 more sources
World Journal of Clinical Oncology, 2020 MUTYH is a base excision repair enzyme, it plays a crucial role in the correction of DNA errors from guanine oxidation and may be considered a cell protective factor. In humans it is an adenine DNA glycosylase that removes adenine misincorporated in 7,8-dihydro-8-oxoguanine (8-oxoG) pairs, inducing G:C to T:A transversions.
Curia MC, Catalano T, Aceto GM.
openaire +3 more sources
Liver Research, 2022 Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. The development of biomarkers for early detection and monitoring of HCC has not shown significant progress.
Fan Yang +7 more
doaj +1 more source
Association of MUTYH and colorectal cancer [PDF]
British Journal of Cancer, 2006 Mutations in the MUTYH gene have been reported to be associated with increased risk of developing colorectal cancer. In this study, we confirmed this association using original data on 928 colorectal cancer cases and 845 healthy controls from Scotland.
Tenesa, A +5 more
openaire +3 more sources
The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis. [PDF]
PLoS ONE, 2010 BACKGROUND: The Mutyh DNA glycosylase is involved in the repair of oxidized DNA bases. Mutations in the human MUTYH gene are responsible for colorectal cancer in familial adenomatous polyposis.
Ida Casorelli +10 more
doaj +1 more source
Molecular genetic testing in colon cancer: clinical aspects
Alʹmanah Kliničeskoj Mediciny, 2022 Molecular genetic diagnostics is an essential element to plan for management of colorectal cancer (CRC) patients. The choice of systemic treatment for CRC is impossible without molecular testing of the tumor.
Aleksandr S. Martianov +3 more
doaj +1 more source
International Journal of Occupational Medicine and Environmental Health, 2022 Objectives Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer. In this work authors investigate influence of selected polymorphisms of DNA repair genes ( XRCC1 , OGG1 and MUTYH ) and level of ...
Jacek Kabziński, Ireneusz Majsterek
doaj +1 more source
Case Report: The Role of Molecular Analysis of the MUTYH Gene in Asymptomatic Individuals
Frontiers in Genetics, 2020 MUTYH-associated polyposis (MAP) is a rare hereditary condition caused by the biallelic mutation in the MUTYH gene encoding MUTYH glycosylase. This enzyme is a key member of the base excision repair (BER) pathway responsible for the repair of DNA lesions
Katarína Fabišíková +5 more
doaj +1 more source
Base excision repair and the role of MUTYH [PDF]
Hereditary Cancer in Clinical Practice, 2007 The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development. The mechanisms underlying the process of base excision repair are relatively well understood and are placed in context with how ...
Kairupan, Carla, Scott, Rodney J.
openaire +5 more sources
Non-coding RNA Research, 2019 The human gene MUTYH codes for a DNA glycosylase involved in the repair of oxidative DNA damage. Faulty MUTYH protein activity causes the accumulation of G→T transversions due to unrepaired 8-oxoG:A mismatches.
Zainularifeen Abduljaleel +4 more
doaj +1 more source