Results 21 to 30 of about 52,376 (272)
Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS [PDF]
, 2012 Myasthenia Gravis (MG) patients suffer from chronic fatigue of skeletal muscles, even after initiation of proper immunosuppressive medication. Since the localization of neuronal nitric oxide synthase (nNOS) at the muscle membrane is important for ...
Meinen, Sarina +7 more
core +2 more sources
Quality of life in purely ocular myasthenia in Japan [PDF]
, 2014 Background: Since there has been no conclusive evidence regarding the treatment of ocular myasthenia, treatment guidelines were recently issued by the European Federation of Neurological Societies/European Neurological Society (EFNS/ENS).
Murai, Hiroyuki +23 more
core +2 more sources
Minimally invasive techniques in thymic surgery (review of literature)
Вестник хирургии имени И.И. Грекова, 2021 We carried out the systematic review of the domestic and foreign literature focusing on surgical treatment of patients with thymic pathology. Special attention was paid to the discussion of the advantages of minimally invasive surgery, particularly ...
O. V. Pikin +3 more
doaj +1 more source
Exploring the Value of Quantitative Muscle Ultrasound in Neuromuscular Junction Disorders: A Pilot Study. [PDF]
Muscle NerveABSTRACT Introduction/Aims Quantitative muscle ultrasound (QMUS) is a validated technique for assessing muscle pathology, yet its role in disorders primarily affecting the neuromuscular junction (NMJ) remains unclear. This pilot study aimed to explore whether QMUS is associated with structural muscle changes in patients with acquired or genetic NMJ ...
Pogosean A +3 more
europepmc +2 more sources
Chronic mimics of myasthenia gravis: a retrospective case series
, 2023 Myasthenia gravis often presents a diagnostic challenge and may be misdiagnosed, particularly in seronegative disease with active symptoms. We retrospectively evaluated 61 patients following the introduction of single fibre electromyography at our ...
Winkel, Antony +2 more
core +1 more source
Analysis of nAChR Autoantibodies Against Extracellular Epitopes in MG Patients
Frontiers in Neurology, 2022 Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies targeting components of the postsynaptic membrane of the neuromuscular junction (NMJ), leading to neuromuscular transmission deficiency.
Maria Michail +6 more
doaj +1 more source
Neurological Adverse Events Associated With Immune Checkpoint Inhibitors Identified Through Disproportionality Analysis of the FDA Adverse Event Reporting System. [PDF]
Cancer MedABSTRACT Background Neurological immune‐related adverse events (N‐irAEs) from immune checkpoint inhibitors (ICIs) are rare but potentially fatal. This study aimed to characterize their real‐world profile to support early detection and management.
Chen T +5 more
europepmc +2 more sources
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Classical complement pathway in experimental autoimmune myasthenia gravis pathogenesis
, 2021 Mice deficient for complement factors C3, C4, or C5 are resistant to experimental autoimmune myasthenia gravis (EAMG). Acetylcholine receptor (AChR) immune lymph node cells (LNC) of C3 deficient mice produce less interleukin 6 (IL-6), and EAMG-resistant ...
CHRISTADOSS, Premkumar +4 more
core +1 more source
Frontiers in NeurologyBackground and purposeMyasthenia gravis (MG) is characterized by fluctuating muscle weakness due to immune-mediated damage to acetylcholine receptors. Viral infections can exacerbate symptoms of muscle weakness, and the clinical status of patients with ...
Peng Liu +8 more
doaj +1 more source