Results 1 to 10 of about 35,534 (303)
IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression [PDF]
Molecular Cancer, 2023 Background Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma relapse, emphasizing the need of novel drug targets and therapeutic strategies.
Sven Hagemann +10 more
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MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
Nature Cancer, 2022 Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYCN induces
Hamed Alborzinia +2 more
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Prognostic significance of MYCN related genes in pediatric neuroblastoma: a study based on TARGET and GEO datasets [PDF]
BMC Pediatrics, 2020 Background Neuroblastoma patients with MYCN amplification are associated with poor prognosis. However, the prognostic relevance of MYCN associated genes in neuroblastoma is unclear. Methods The expression profiles of MYCN associated genes were identified
Haiwei Wang +4 more
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MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma
Cell Death and Disease, 2021 MYCN amplification is tightly associated with the poor prognosis of pediatric neuroblastoma (NB). The regulation of NB cell death by MYCN represents an important aspect, as it directly contributes to tumor progression and therapeutic resistance. However,
Jin-Xin Bei, Chaoyun Pan, Xiaoqiong Gu
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Frontiers in Cell and Developmental Biology, 2021 Although a rare disease, neuroblastoma accounts for the highest proportion of childhood cancer deaths. There is a lack of recurrent somatic mutations in neuroblastoma embryonal tumours, suggesting a possible role for epigenetic alterations in driving ...
Aleksandar Krstic +12 more
doaj +2 more sources
Upstream ORF affects MYCN translation depending on exon 1b alternative splicing [PDF]
BMC Cancer, 2009 Background The MYCN gene is transcribed into two major mRNAs: one full-length (MYCN) and one exon 1b-spliced (MYCNΔ1b) mRNA. But nothing is known about their respective ability to translate the MYCN protein.
Tutrone Giovani +9 more
doaj +2 more sources
Targeting MYCN in Pediatric and Adult Cancers
Frontiers in Oncology, 2021 The deregulation of the MYC family of oncogenes, including c-MYC, MYCN and MYCL occurs in many types of cancers, and is frequently associated with a poor prognosis.
Zhihui Liu +4 more
doaj +2 more sources
Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
Nature Communications, 2020 MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA).
Konstantin Helmsauer +2 more
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Nature Communications, 2021 To achieve the very high oncoprotein levels required to drive the malignant state cancer cells utilise the ubiquitin proteasome system to upregulate transcription factor levels.
Janith Ananda Seneviratne +2 more
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A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma
Communications BiologyRetinoblastoma are childhood eye tumors arising from retinal precursor cells. Two distinct retinoblastoma subtypes with different clinical behavior have been described based on gene expression and methylation profiling.
Tatsiana Ryl +19 more
doaj +2 more sources