Results 121 to 130 of about 35,534 (303)

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. [PDF]

, 2018
RationaleMutations in the transcription factor TBX20 (T-box 20) are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by embryonic day 9.5.
Aneas, Ivy, Bogomolovas, Julius, Boogerd, Cornelis J, Chen, Ju, Evans, Sylvia M, Joslin, Amelia C, Montefiori, Lindsey, Nobrega, Marcelo A, Sakabe, Noboru, Sobreira, Debora R, Zhang, Lunfeng, Zhou, Bin, Zhu, Xiaoming   +12 more
core   +2 more sources

Precision Oncology for Pediatric Solid Tumors Using In‐Hospital Pediatric/AYA Malignancy‐Specific Panel Sequencing

Cancer Science, EarlyView.
Our findings indicate that a pediatric/AYA‐specific targeted panel deployed in a hospital can deliver rapid, clinically actionable molecular insights with high diagnostic and prognostic yield. This complements larger sequencing platforms by offering speed, focused content, and easier interpretation.
Masato Kojima, Sho Kurihara, Isamu Saeki, Ryo Touge, Keigo Nakashima, Shuhei Karakawa, Fumiyuki Yamasaki, Satoshi Okada, Eiso Hiyama   +8 more
wiley   +1 more source

Therapeutic potential of targeting MYCN

Medicine, 2020
Neuroblastoma (NB) with MYCN amplification has a poor prognosis and high mortality. The potential molecular biological relationship between clinical features and MYCN amplification should be explored.NB patients were examined by fluorescence in situ hybridization (FISH) for MYCN amplification in the tumor mass or bone marrow samples to determine ...
Huang, Can, Jiang, Shayi, Yang, Jingwei, Liao, Xuelian, Li, Yanhua, Li, Shanshan   +5 more
openaire   +2 more sources

Age related gene DST represents an independent prognostic factor for MYCN non-amplified neuroblastoma

BMC Pediatrics, 2021
Background MYCN amplification and age are two critical prognostic factors of pediatric neuroblastoma. Previously, we had revealed the prognosis of MYCN target genes.
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang, Hua Cao   +4 more
doaj   +1 more source

Action of HMGB1 on miR221/222 cluster in neuroblastoma cell lines [PDF]

, 2016
microRNA (miR/miRNA) are small non-coding RNAs that control gene expression at the post-transcriptional level by targeting mRNAs. Aberrant expression of miRNAs is often observed in different types of cancer.
Fico, F, Mardente, Stefania, Mari, Emanuela, Martina, L, Massimi, Isabella, Zicari, Alessandra   +5 more
core   +1 more source

MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

Genes & Development, 2020
Here, Grunblatt et al. sought to understand the roles for MYCN amplification in SCLC progression and chemoresistance, and developed a genetically engineered mouse model of MYCN-overexpressing SCLC. Their findings show that MYCN overexpression drives SCLC
E. Grunblatt, N. Wu, Huajia Zhang, Xiaoli Liu, Xiaoli Liu, J. P. Norton, Yamini M. Ohol, P. Leger, Joseph B Hiatt, Emily Eastwood, Rhiana Thomas, Ali H. Ibrahim, D. Jia, Ryan S Basom, K. Eaton, R. Martins, A. M. Houghton, D. MacPherson, D. MacPherson   +18 more
semanticscholar   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines [PDF]

, 2017
Neuroblastoma cell lines are an important and cost-effective model used to study oncogenic drivers of the disease. While many of these cell lines have been previously characterized with SNP, methylation, and/or mRNA expression microarrays, there has not ...
Adams, Rebecca N., Davidson, Heather L., Dent, Maiah H., Diamond, Maura A., FORTINA, PAOLO, Harenza, Jo Lynne, Hart, Lori S., Maris, John M., Reynolds, C. Patrick, Song, Michael M.   +9 more
core   +2 more sources

High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma

Acta Neuropathologica Communications, 2020
We report a novel group of clinically aggressive spinal cord ependymomas characterized by Grade III histology, MYCN amplification, an absence of NF2 alterations or other recurrent pathogenic mutations, and a unique methylation classifier profile.
M. Raffeld, Zied Abdullaev, S. Pack, L. Xi, Sushma Nagaraj, Nicole J Briceno, Elizabeth Vera, S. Pittaluga, Osorio Lopes Abath Neto, M. Quezado, K. Aldape, T. Armstrong, M. Gilbert   +12 more
semanticscholar   +1 more source

Radiogenomics: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 2, February 2026.
Radiogenomics links imaging phenotypes with genetic variations, offering potential for comprehensive understanding, cost‐effective diagnosis, and prognosis prediction to advance personalized medicine. However, its clinical application remains limited by several challenges.
Xinyu Zhang, Qingpei Lai, Jin Cao, Jerry Chi Fung Ching, Xinzhi Teng, Jiang Zhang, Shara Wee Yee Lee, Ge Ren, Jing Cai   +8 more
wiley   +1 more source