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MYCN as a target for cancer immunotherapy
Cancer Immunology, Immunotherapy, 2007MYCN is a potential target for cancer immunotherapy by virtue of its overexpression in numerous human malignancies and its functional role in tumour progression. Here we show limited expression of MYCN in normal human tissues indicating that anti-MYCN immune responses are unlikely to cross react with self tissues.
Nourredine, Himoudi +3 more
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The MYCN oncogene and differentiation in neuroblastoma
Seminars in Cancer Biology, 2011Childhood neuroblastoma exhibits a heterogeneous clinical behavior ranging from low-risk tumors with the ability to spontaneously differentiate and regress, to high-risk tumors causing the highest number of cancer related deaths in infants. Amplification of the MYCN oncogene is one of the few prediction markers for adverse outcome.
Ulrica K, Westermark +3 more
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ALK pERKs Up MYCN in Neuroblastoma
Science Signaling, 2014Identification of a crucial mediator between abnormally active ALK and MYCN reveals a potential combination therapy for several tumor types.
Lindner, Sven +3 more
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Locoregional MYCN‐amplified neuroblastoma
Pediatric Blood & Cancer, 2012AbstractMYCN‐amplification is strongly associated with other high‐risk prognostic factors and poor outcome in neuroblastoma. Infrequently, amplification of MYCN has been identified in localized tumors with favorable biologic features. Outcome for these children is difficult to predict and optimal treatment strategies remain unclear. We report a 5‐month‐
Morales La Madrid A +8 more
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Cavitary retinoblastoma with MYCN amplification
Journal of American Association for Pediatric Ophthalmology and StrabismusMYCN amplification within the tumor has emerged as an important factor in the oncogenesis of a subset of retinoblastomas, most of which are caused by pathogenic variants in the RB1 gene. We present the case of a 3-month-old girl with unilateral cavitary retinoblastoma that initially responded well to intra-arterial chemotherapy but later recurred ...
Kathryn E. Tobert +3 more
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Circulating MYCN DNA Predicts MYCN-Amplification in Neuroblastoma
Journal of Clinical Oncology, 2005Valérie, Combaret +4 more
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The MYCN/Aurora-A/CDK12 axis as a critical target in MYCN amplified neuroblastoma [PDF]
Neuroblastoma is the most common extracranial solid tumor of early childhood. Tumors driven by amplification of the oncogene MYCN exhibit aggressive clinical behavior and poor prognosis despite multimodal therapy. Previous in vitro studies have shown that complex formation between MYCN and the Aurora-A kinase stabilizes MYCN while also activating ...
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The MYCN Enigma: Significance of MYCN Expression in Neuroblastoma
Yearbook of Oncology, 2007openaire +1 more source