Results 31 to 40 of about 35,534 (303)

MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis

Cancer Research, 2021
The study shows how MYCN increases intracellular iron levels and subsequent GSH pathway activity and demonstrates the antitumor activity of FDA-approved SAS and auranofin in patient-derived xenograft models of MYCN-amplified neuroblastoma.
K. Floros, Jinyang Cai, Sheeba Jacob, Richard I. J. Kurupi, Carter K. Fairchild, Mayuri Shende, Colin M. Coon, Krista M. Powell, B. Belvin, Bin Hu, Madhavi Puchalapalli, S. Ramamoorthy, Kimberly Swift, J. Lewis, M. Dozmorov, J. Glod, Jennifer E. Koblinski, S. Boikos, A. Faber   +18 more
semanticscholar   +1 more source

RNA N6-methyladenosine reader IGF2BP3 interacts with MYCN and facilitates neuroblastoma cell proliferation

Cell Death Discovery, 2023
Neuroblastoma (NB) is a kind of typical life-threatening extracranial tumor in children. N6-methyladenosine (m6A) modification is closely related to multiple cancer pathological processes.
Kai Zhu, Tingting Gao, Zhiru Wang, Liaoran Zhang, Kezhe Tan, Zhibao Lv   +5 more
semanticscholar   +1 more source

CCNB1IP1 prevents ubiquitination‐mediated destabilization of MYCN and potentiates tumourigenesis of MYCN‐amplificated neuroblastoma

Clinical and Translational Medicine, 2023
Background MYCN amplification as a common genetic alteration that correlates with a poor prognosis for neuroblastoma (NB) patients. However, given the challenge of directly targeting MYCN, indirect strategies to modulate MYCN by interfering with its ...
Yang Zhou, Hui Yan, Qiang Zhou, Penggao Wang, Fang Yang, Ziqiao Yuan, Qianming Du, Bo Zhai   +7 more
doaj   +1 more source

The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma

Science Advances, 2023
MYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcriptional amplification.
Donghai Wang, Zhinang Yin, Honghong Wang, Liyuan Wang, Tianyu Li, Ruijing Xiao, Ting Xie, Ruyi Han, Rui Dong, Hudan Liu, Kaiwei Liang, Guoliang Qing   +11 more
semanticscholar   +1 more source

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma

International Journal of Molecular Sciences, 2023
Amplification of the MYCN oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN in NB, the exact molecular mechanisms underlying MYCN’s ...
P. Agarwal, A. Głowacka, Loay Mahmoud, Wesam Bazzar, L. Larsson, Mohammad Alzrigat   +5 more
semanticscholar   +1 more source

Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice

Stem Cell Research & Therapy, 2022
Background Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a proto-oncogene
Zhuo Huang, Ruihuan Yang, Ruyi Li, Yining Zuo, Fan Gu, Miao He, Zhuan Bian   +6 more
doaj   +1 more source

Ceftriaxone exerts antitumor effects in MYCN‐driven retinoblastoma and neuroblastoma by targeting DDX3X for translation repression

Molecular Oncology, 2023
MYCN proto‐oncogene, bHLH transcription factor (MYCN) amplification is associated with aggressive retinoblastoma (RB) and neuroblastoma (NB) cancer recurrence that is resistant to chemotherapies.
Pamorn Chittavanich, D. Saengwimol, S. Roytrakul, Duangnate Rojanaporn, Vijender Chaitankar, Atthapol Srimongkol, U. Anurathapan, S. Hongeng, R. Kaewkhaw   +8 more
semanticscholar   +1 more source

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures

Nature Communications, 2023
Pediatric high-grade gliomas of the subclass MYCN (HGG-MYCN) are highly aggressive tumors frequently carrying MYCN amplifications, TP53 mutations, or both alterations.
Melanie Schoof, Shweta Godbole, T. Albert, M. Dottermusch, C. Walter, Annika Ballast, N. Qin, Marlena Baca Olivera, C. Göbel, S. Neyazi, D. Holdhof, C. Kresbach, Levke-Sophie Peter, Gefion Dorothea Epplen, V. Thaden, M. Spohn, Mirjam Blattner-Johnson, F. Modemann, M. Mynarek, S. Rutkowski, M. Sill, J. Varghese, Ann-Kristin Afflerbach, Alicia Eckhardt, Daniel Münter, Archana Verma, N. Struve, David T W Jones, M. Remke, J. Neumann, K. Kerl, U. Schüller   +31 more
semanticscholar   +1 more source

Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation. [PDF]

PLoS ONE, 2009
BACKGROUND:Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths.
Derek M Murphy, Patrick G Buckley, Kenneth Bryan, Sudipto Das, Leah Alcock, Niamh H Foley, Suzanne Prenter, Isabella Bray, Karen M Watters, Desmond Higgins, Raymond L Stallings   +10 more
doaj   +1 more source

An E2F5-TFDP1-BRG1 Complex Mediates Transcriptional Activation of MYCN in Hepatocytes

Frontiers in Cell and Developmental Biology, 2021
Liver regeneration is characterized by cell cycle reentrance of hepatocytes. N-Myc, encoded by MYCN, is a member of the Myc family of transcription factors.
Zhiwen Fan, Zhiwen Fan, Ming Kong, Xiulian Miao, Yan Guo, Haozhen Ren, Haozhen Ren, Jinglin Wang, Jinglin Wang, Shuai Wang, Shuai Wang, Ning Tang, Ning Tang, Longcheng Shang, Zhengyi Zhu, Hanyi Liu, Wei Zhu, Xiaolei Shi, Xiaolei Shi   +18 more
doaj   +1 more source