Results 41 to 50 of about 35,534 (303)

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma

Nature Communications, 2022
Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification is found in half of high-risk NB patients; however, no available therapies directly target MYCN.
Ling Tao, Mahmoud A. Mohammad, G. Milazzo, Myrthala Moreno-Smith, Tajhal D. Patel, B. Zorman, Andrew A. Badachhape, Blanca E. Hernandez, Amber B. Wolf, Zihua Zeng, Jennifer H. Foster, Sara Aloisi, Pavel Sumazin, Y. Zu, John Hicks, K. B. Ghaghada, N. Putluri, Giovanni Perini, C. Coarfa, Eveline Barbieri   +19 more
semanticscholar   +1 more source

Antigene MYCN Silencing by BGA002 Inhibits SCLC Progression Blocking mTOR Pathway and Overcomes Multidrug Resistance

Cancers, 2023
Simple Summary Small-cell lung cancer (SCLC) is the most aggressive form of lung cancer, is mostly associated with smoking and has a low survival rate.
Sonia Bortolotti, Silvia Angelucci, L. Montemurro, Damiano Bartolucci, Salvatore Raieli, S. Lampis, Camilla Amadesi, A. Scardovi, Giammario Nieddu, Lucia Cerisoli, F. Paganelli, F. Chiarini, G. Teti, M. Falconi, A. Pession, P. Hrelia, R. Tonelli   +16 more
semanticscholar   +1 more source

Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]

, 2014
This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Frenzel, Anna, Henriksson, Marie Arsenian, Larsson, Karin, Muller, Inga, Oliynyk, Ganna, Prochownik, Edward V., Westwood, Nicholas J., Zirath, Hanna   +7 more
core   +3 more sources

MYCN Impact on High-Risk Neuroblastoma: From Diagnosis and Prognosis to Targeted Treatment

Cancers, 2022
Simple Summary Neuroblastoma is one of the most diffuse and the deadliest cancer in children. While many advances have been made in the last few decades to improve patients’ outcome, high-risk neuroblastoma (HR-NB) still shows a very aggressive pattern ...
Damiano Bartolucci, L. Montemurro, Salvatore Raieli, S. Lampis, A. Pession, P. Hrelia, R. Tonelli   +6 more
semanticscholar   +1 more source

Dangerous liaisons: MYCN meets condensins [PDF]

Cell Cycle, 2014
(2014). Dangerous liaisons: MYCN meets condensins. Cell Cycle: Vol. 13, No. 8, pp. 1225-1226.
Y. J. Achar, M. Foiani
openaire   +3 more sources

Enhancer of zeste homolog 2 regulates cell differentiation and proliferation in neuroblastoma

Universa Medicina, 2014
BACKGROUND Neuroblastoma  (NB)  is  one  of  the  most  common  extracranial  solid  tumors occurring in infancy and childhood with highly variable outcomes. Polycomb group (PcG) proteins are epigenetic gene silencers.
Amallia N. Setyawati, Takehiko Kamijo
doaj   +1 more source

Implementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma

Molecular Oncology, 2020
Detection of amplification of the MYCN gene is essential for determining optimal treatment and estimating prognosis of patients with neuroblastoma (NB).
Yan Su, Lijun Wang, Qian Zhao, Zhixia Yue, Wen Zhao, Xisi Wang, Chao Duan, Mei Jin, Dawei Zhang, Shenglan Chen, Jianfeng Yin, Lihua Qiu, Xianfeng Cheng, Zhong Xu, Xiaoli Ma   +14 more
doaj   +1 more source

Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells [PDF]

, 2015
This research was originally published in Journal of Biological Chemistry. Olesya Chayka, Cosimo Walter D’Acunto, Odette Middleton, Maryam Arab, and Arturo Sala.
Arab, M, Chayka, O, D'Acunto, CW, Middleton, O, Sala, A   +4 more
core   +1 more source

The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells

BMC Cancer, 2018
Background MYCN is amplified in small cell lung cancers and several pediatric tumors, including alveolar rhabdomyosarcomas and neuroblastomas. MYCN protein is known to play a key oncogenic role in both alveolar rhabdomyosarcomas and neuroblastomas.
Eleanor M. O’Brien, Joanna L. Selfe, Ana Sofia Martins, Zoë S. Walters, Janet M. Shipley   +4 more
doaj   +1 more source

Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma. [PDF]

, 2017
A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification.
Bhatti, Tricia R., Eagle Jr., Ralph C., Ewens, Kathryn G., Ganguly, Arupa, Moran, Kimberly A., Richards-Yutz, Jennifer, Shields, Carol L.   +6 more
core   +2 more sources