The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress [PDF]
, 2015 The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/
A Dupre +70 more
core +1 more source
Abstract High-risk neuroblastoma is one of the most lethal childhood cancers. Half of these tumors are driven by MYCN gene amplification (MNA). Despite intensive chemo- and radiotherapy, only 40% of patients survive, and they often suffer from severe long-term side effects of these genotoxic treatments.
Soraya Epp +11 more
openalex +2 more sources
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Cancer Discovery, 2021 Targeted degradation of EP300 with a novel PROTAC agent in neuroblastoma cells was found to cause widespread loss of gene expression and cell death in vitro and in vivo.
A. Durbin +28 more
semanticscholar +1 more source
MYCN in Neuroblastoma: “Old Wine into New Wineskins”
Diseases, 2021 MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent ...
Maria Braoudaki +3 more
doaj +1 more source
VLT observations of the asymmetric Etched Hourglass Nebula, MyCn 18 [PDF]
, 2014 Context. The mechanisms that form extreme bipolar planetary nebulae remain unclear. Aims. The physical properties, structure, and dynamics of the bipolar planetary nebula, MyCn 18, are investigated in detail with the aim of understanding the shaping ...
Clyne, N. +5 more
core +2 more sources
Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification [PDF]
Proceedings of the National Academy of Sciences, 2012 Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor prognosis.
Valentijn, Linda J. +8 more
openaire +3 more sources
Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival [PDF]
, 2009 MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of cancer, including neuroblastoma, an often fatal paediatric cancer originating from precursor cells
Alcock, L. +15 more
core +8 more sources
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]
, 2020 Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles +3 more
core +1 more source
Science Advances, 2022 High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identification of drivers
C. Nunes +41 more
semanticscholar +1 more source
The MYCN Enigma: Significance of MYCN Expression in Neuroblastoma [PDF]
Cancer Research, 2006 Abstract MYCN amplification strongly predicts adverse outcome of neuroblastoma. However, the significance of MYCN expression in the clinical and biological behavior of neuroblastoma has been unclear. To address this question, we first examined the expression of MYCN in combination with TrkA (a favorable prognostic indicator of ...
Xao X, Tang +9 more
openaire +2 more sources