Results 61 to 70 of about 35,534 (303)

Neuroblastoma: Anti‐Invasive Effects of Tetracaine In Vitro* [PDF]

open access: yesBasic Clin Pharmacol Toxicol
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
Selçuk E   +7 more
europepmc   +2 more sources

Molecular Mechanisms of MYCN Dysregulation in Cancers

open access: yesFrontiers in Oncology, 2021
MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma
Ruochen Liu   +4 more
semanticscholar   +1 more source

MYCN gene amplification in rhabdomyosarcoma [PDF]

open access: yesCancer, 1994
Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is the clearest example of a clinically relevant oncogene mutation in any human cancer.The incidence and clinical significance of MYCN amplification in rhabdomyosarcoma ...
D, Driman   +4 more
openaire   +2 more sources

Molecular Heterogeneity in Neuroblastoma and Its Clinical Significance

open access: yesJournal of Behçet Uz Children's Hospital, 2023
Objective: Tumor heterogeneity describes the differences between cancer cells in the same tumor sample. Neuroblastoma (NB) is a type of cancer where tumor heterogeneity complicates its treatment.
Tekincan Çağrı Aktaş   +8 more
doaj   +1 more source

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas [PDF]

open access: yes, 2018
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking.
Abdel-Rahman, Mohamed H.   +740 more
core   +2 more sources

On the utility of RNA sample pooling to optimize cost and statistical power in RNA sequencing experiments [PDF]

open access: yes, 2020
Background: In gene expression studies, RNA sample pooling is sometimes considered because of budget constraints or lack of sufficient input material. Using microarray technology, RNA sample pooling strategies have been reported to optimize both the cost
Assefa, Alemu Takele   +2 more
core   +2 more sources

FOXR2 Stabilizes MYCN Protein and Identifies Non–MYCN-Amplified Neuroblastoma Patients With Unfavorable Outcome [PDF]

open access: yesJournal of Clinical Oncology, 2021
PURPOSE Clinical outcomes of patients with neuroblastoma range from spontaneous tumor regression to fatality. Hence, understanding the mechanisms that cause tumor progression is crucial for the treatment of patients. In this study, we show that FOXR2 activation identifies a subset of neuroblastoma tumors with unfavorable outcome and we investigate the ...
Felix Schmitt-Hoffner   +12 more
openaire   +2 more sources

Opportunities and challenges of circulating biomarkers in neuroblastoma [PDF]

open access: yesOpen Biology, 2019
Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics. However, many current and emerging biomarkers are based on analysis
Ricky M. Trigg   +2 more
doaj   +1 more source

A novel and universal method for microRNA RT-qPCR data normalization [PDF]

open access: yes, 2009
Gene expression analysis of microRNA molecules is becoming increasingly important. In this study we assess the use of the mean expression value of all expressed microRNAs in a given sample as a normalization factor for microRNA real-time quantitative PCR
De Weer, An   +6 more
core   +2 more sources

ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation

open access: yesEMBO Journal, 2021
High‐risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to cancer. One indicator of high‐risk NB is amplification of the neural MYC (MYCN) oncogene, which is currently therapeutically intractable.
Marcus Borenäs   +18 more
semanticscholar   +1 more source

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