Results 81 to 90 of about 35,534 (303)

MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma

Oncogenesis, 2022
Retinoblastoma is a rare, intraocular paediatric cancer that originates in the neural retina and is most frequently caused by bi-allelic loss of RB1 gene function. Other oncogenic mutations, such as amplification and increased expression of the MYCN gene,
Maria K. E. Blixt, Minas Hellsand, Dardan Konjusha, Hanzhao Zhang, Sonya Stenfelt, Mikael Åkesson, N. Rafati, Tatsiana Tararuk, Gustav Stålhammar, Charlotta All-Eriksson, Henrik Ring, F. Hallböök   +11 more
semanticscholar   +1 more source

Downregulation of MYCN through PI3K inhibition in mouse models of pediatric neural cancer

Frontiers in Oncology, 2015
The MYCN proto-oncogene is associated with poor outcome across a broad range of pediatric tumors. While amplification of MYCN drives subsets of high risk neuroblastoma and medulloblastoma, dysregulation of MYCN in medulloblastoma (in the absence of ...
Tene Aneka Cage, Yvan eChanthery, Yvan eChanthery, Louis eChesler, Matthew eGrimmer, Matthew eGrimmer, Zachary eKnight, Kevan eShokat, William A Weiss, William A Weiss, William A Weiss, William A Weiss, W. Clay Gustafson, W. Clay Gustafson   +13 more
doaj   +1 more source

Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN

Cell Death and Disease, 2023
The transcription factor MYCN is frequently amplified and overexpressed in a variety of cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation, survival, and migration.
Xiaoling Zhang, Xianling Cong, Xiangting Jin, Yu’e Liu, Tong Zhang, Xinyuan Fan, Xiyao Shi, Xiaoying Zhang, Xue Wang, Yong-Guang Yang, Xiangpeng Dai   +10 more
doaj   +1 more source

A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence [PDF]

Journal of Clinical Investigation, 2017
The most frequent focal alterations in human retinoblastoma are mutations in the tumor-suppressor gene retinoblastoma (RB) and amplification of the oncogene MYCN. Whether MYCN overexpression drives retinoblastoma has not been assessed in model systems. Here, we have shown that Rb inactivation collaborates strongly with MYCN overexpression and leads to ...
Nan, Wu, Deshui, Jia, Breanna, Bates, Ryan, Basom, Charles G, Eberhart, David, MacPherson   +5 more
openaire   +2 more sources

Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: Functional and therapeutic implications [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.CLU (clusterin) is a tumor suppressor gene that we have previously shown to be negatively modulated ...
Cantilena, S, Chayka, O, Corvetta, D, D'Acunto, CW, Gherardi, S, Perini, G, Piotrowska, I, Sala, A, Valli, E   +8 more
core   +1 more source

MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma

Cell Death and Disease
MYCN amplification is an independent poor prognostic factor in patients with high-risk neuroblastoma (NB). Further exploring the molecular regulatory mechanisms in MYCN-amplified NB will help to develop novel therapy targets.
J. Guan, Mengzhen Li, Yi Wang, Yu Zhang, Yi Que, Suying Lu, Juan Wang, Jia Zhu, Junting Huang, Z. Zhen, F. Sun, Mengjia Song, Yizhuo Zhang   +12 more
semanticscholar   +1 more source

Biological effects of induced MYCN hyper-expression in MYCN-amplified neuroblastomas

International Journal of Oncology, 2010
Neuroblastoma is a childhood malignancy of the sympathetic nervous system. The tumor exhibits two different phenotypes: favorable and unfavorable. MYCN amplification is associated with rapid tumor progression and the worst neuroblastoma disease outcome.
Jaime, Torres, Paul L, Regan, Robby, Edo, Payton, Leonhardt, Eric I, Jeng, Eric F, Rappaport, Naohiko, Ikegaki, Xao X, Tang   +7 more
openaire   +3 more sources

A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN -amplified neuroblastoma

Science Advances, 2023
MYCN amplification ( MNA ) is a defining feature of high-risk neuroblastoma (NB) and predicts poor prognosis. However, whether genes within or in close proximity to the MYCN amplicon also contribute to MNA + NB ...
Hai-Feng Zhang, Alberto Delaidelli, Sumreen Javed, Busra Turgu, Taylor Morrison, Christopher S. Hughes, Xiaqiu Yang, Manideep Pachva, Michael M. Lizardo, Gurdeep Singh, Jennifer Hoffmann, Yue Zhou Huang, Khushbu Patel, Rawan Shraim, Sonia H. Y. Kung, Gregg B. Morin, Samuel Aparicio, Daniel Martinez, John M. Maris, Kristopher R. Bosse, Karla C. Williams, Poul H. Sorensen   +21 more
openaire   +2 more sources

CT-Based Radiomics Signature With Machine Learning Predicts MYCN Amplification in Pediatric Abdominal Neuroblastoma

Frontiers in Oncology, 2021
Purpose MYCN amplification plays a critical role in defining high-risk subgroup of patients with neuroblastoma. We aimed to develop and validate the CT-based machine learning models for predicting MYCN amplification in pediatric abdominal neuroblastoma ...
Xin Chen, Haoru Wang, Kaiping Huang, Huan Liu, H. Ding, Li Zhang, Tingying Zhang, Wenqing Yu, Ling He   +8 more
semanticscholar   +1 more source

Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance

Frontiers in Oncology
Amplification of MYCN is observed in high-risk neuroblastomas (NBs) and is associated with a poor prognosis. MYCN expression is directly regulated by multiple transcription factors, including OCT4, MYCN, CTCF, and p53 in NB.
Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Kazuma Nakatani, Hiroyuki Kogashi, Hiroyuki Kogashi, Takanori Miyamoto, Taiki Setoguchi, Tetsushi Sakuma, Kazuto Kugou, Yoshinori Hasegawa, Takashi Yamamoto, Yoshitaka Hippo, Yoshitaka Hippo, Yoshitaka Hippo, Yusuke Suenaga   +15 more
doaj   +1 more source