Results 1 to 10 of about 10,096 (205)

A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma

Communications Biology
Retinoblastoma are childhood eye tumors arising from retinal precursor cells. Two distinct retinoblastoma subtypes with different clinical behavior have been described based on gene expression and methylation profiling.
Tatsiana Ryl, Elena Afanasyeva, Till Hartmann, Melanie Schwermer, Markus Schneider, Christopher Schröder, Maren Wagemanns, Arthur Bister, Deniz Kanber, Laura Steenpass, Kathrin Schramm, Barbara Jones, David T. W. Jones, Eva Biewald, Kathy Astrahantseff, Helmut Hanenberg, Sven Rahmann, Dietmar R. Lohmann, Alexander Schramm, Petra Ketteler   +19 more
doaj   +1 more source

Increased efficacy of histone methyltransferase G9a inhibitors against MYCN-amplified Neuroblastoma [PDF]

, 2019
Jacob Bellamy, Marianna Szemes, Zsombor Melegh, Anthony R. Dallosso, Madhu Kollareddy, Daniel Catchpoole, Karim Malik   +6 more
openalex   +1 more source

Supplementary Table S2 from Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk <i>MYCN</i>-Not-Amplified Human Neuroblastoma

, 2023
Jun S. Wei, Igor B. Kuznetsov, Shile Zhang, Young Song, Shahab Asgharzadeh, Sivasish Sindiri, Xinyu Wen, Rajesh Patidar, Sushma Najaraj, Ashley Walton, Jaime M. Guidry Auvil, Daniela S. Gerhard, Aysen Yuksel, Daniel Catchpoole, Stephen M. Hewitt, Paul M. Sondel, Robert C. Seeger, John M. Maris, Javed Khan   +18 more
openalex   +2 more sources

Data from <i>MYCN</i>-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis

, 2023
Konstantinos V. Floros, Jinyang Cai, Sheeba Jacob, Richard Kurupi, Carter K. Fairchild, Mayuri Shende, Colin M. Coon, Krista M. Powell, Benjamin R. Belvin, Bin Hu, Madhavi Puchalapalli, Sivapriya Ramamoorthy, Kimberly Swift, Janina P. Lewis, Mikhail G. Dozmorov, John Glod, Jennifer E. Koblinski, Sosipatros A. Boikos, Anthony C. Faber   +18 more
openalex   +1 more source

MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells. [PDF]

Int J Mol Sci, 2023
De Rosa P, Severi F, Zadran SK, Russo M, Aloisi S, Rigamonti A, Capranico G, Milazzo G, Perini G.   +8 more
europepmc   +1 more source

Identification of Crucial Genes Associated With MYCN‐Driven Neuroblastoma Based on Single‐Cell Analysis and Machine Learning

Cancer Medicine
Background Neuroblastoma (NB) with MYCN amplification is strongly correlated with high‐risk stratification and poor prognosis. However, the underlying mechanisms remain incompletely understood.
Jiasi Zhang, Yichen Lei, Yaqin Wang, Wen Yu, Xiaoyan Zhao, Yongbing Zhu, Dedong Zhang, Siying Liu, Aiguo Liu   +8 more
doaj   +1 more source

Extracellular Vesicle-Based Method for Detecting MYCN Amplification Status of Pediatric Neuroblastoma. [PDF]

Cancers (Basel), 2022
Panachan J, Rojsirikulchai N, Pongsakul N, Khowawisetsut L, Pongphitcha P, Siriboonpiputtana T, Chareonsirisuthigul T, Phornsarayuth P, Klinkulab N, Jinawath N, Chiangjong W, Anurathapan U, Pattanapanyasat K, Hongeng S, Chutipongtanate S.   +14 more
europepmc   +1 more source

Combining inhibitors of Brd4 and cyclin-dependent kinase can decrease tumor growth in neuroblastoma with MYCN amplification. [PDF]

J Pediatr Surg, 2021
Wood L, Huang M, Zeki J, Gong M, Taylor J, Shimada H, Chiu B.   +6 more
europepmc   +1 more source

Oxphos Targeting of Mycn -Amplified Neuroblastoma [PDF]

Soraya Epp, Donagh Egan, Evon Poon, Amirah Adlina Abdul Aziz, Kieran Wynne, Melinda Halász, Walter Kölch, Walter Kolch   +7 more
openalex   +1 more source

Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma. [PDF]

Front Oncol, 2022
Keller KM, Eleveld TF, Schild L, van den Handel K, van den Boogaard M, Amo-Addae V, Eising S, Ober K, Koopmans B, Looijenga L, Tytgat GAM, Ylstra B, Molenaar JJ, Dolman MEM, van Hooff SR.   +14 more
europepmc   +1 more source