Results 31 to 40 of about 763,886 (286)

MYCNamplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma [PDF]

OncoTarget, 2015
MYCN amplification occurs in 20% of neuroblastomas and is strongly related to poor clinical outcome. We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this ...
Diana Lau, Claudia L. Flemming, Samuele Gherardi, Giovanni Perini, André Oberthuer, Matthias Fischer, Dilafruz Juraeva, Benedikt Brors, Chengyuan Xue, Murray D. Norris, Glenn M. Marshall, Michelle Haber, Jamie I. Fletcher, Lesley J. Ashton   +13 more
openalex   +2 more sources

MYCN in Neuroblastoma: “Old Wine into New Wineskins” [PDF]

Diseases, 2021
MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent ...
Maria Braoudaki, Kyriaki Hatziagapiou, Apostolos Zaravinos, George I. Lambrou   +3 more
doaj   +3 more sources

Effects of preoperative chemotherapy on neuroblastoma with MYCN amplification: a surgeon's perspective. [PDF]

World J Pediatr Surg, 2020
BackgroundPreoperative chemotherapy plays an important role in the surgical management of unresectable neuroblastoma. Its response to chemotherapy has been variable due to the tumor’s heterogeneity. We aimed to evaluate the effects of preoperative chemotherapy onMYCN-amplified (MYCNA) neuroblastoma that would impact on surgical resection ...
Chui C.
europepmc   +5 more sources

Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification. [PDF]

Cell Adh Migr, 2017
Neuroblastomas are highly invasive tumors that occur in pediatric patients and treatment of invasive disease remains a challenge. The study of cells invading in 3-dimensional (3D) hydrogels has revealed morphologically distinct modes of invasion by which
Mitchell CB, O'Neill GM.
europepmc   +2 more sources

The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells

EBioMedicine, 2015
Dysregulated expression of MYC family genes is a hallmark of many malignancies. Unfortunately, these proteins are not amenable to blockade by small molecules or protein-based therapeutic agents.
Long Gu, Peiguo Chu, Robert Lingeman, Heather McDaniel, Steven Kechichian, Robert J. Hickey, Zheng Liu, Yate-Ching Yuan, John A. Sandoval, Gregg B. Fields, Linda H. Malkas   +10 more
doaj   +2 more sources

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: Four cases of homozygous deletions of the CDKN2A gene [PDF]

BMC Genomics, 2008
Background Neuroblastoma is a very heterogeneous pediatric tumor of the sympathetic nervous system showing clinically significant patterns of genetic alterations.
Kogner Per, Abrahamsson Jonas, Sjöberg Rose-Marie, Enerbäck Charlotta, Olsson Linda, Erichsen Jennie, Carén Helena, Martinsson Tommy   +7 more
doaj   +4 more sources

Detection of MYCN Amplification in Neuroblastoma using Competitive PCR Quantitation [PDF]

Laboratory Investigation, 2000
M E Oude Luttikhuis, Venkateswaran K. Iyer, Sarah Dyer, Pramilla Ramani, Carmel McConville   +4 more
openalex   +3 more sources

Impact of Genomic and Clinical Factors on Outcome of Children ≥18 Months of Age with Stage 3 Neuroblastoma with Unfavorable Histology and without MYCN Amplification: A Children's Oncology Group (COG) Report. [PDF]

Clin Cancer Res, 2023
Pinto N, Naranjo A, Ding X, Zhang FF, Hibbitts E, Kennedy R, Tibbetts R, Wong-Michalak S, Craig DW, Manojlovic Z, Hogarty MD, Kreissman S, Bagatell R, Irwin MS, Park JR, Asgharzadeh S.   +15 more
europepmc   +3 more sources

Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma. [PDF]

Front Oncol, 2022
Keller KM, Eleveld TF, Schild L, van den Handel K, van den Boogaard M, Amo-Addae V, Eising S, Ober K, Koopmans B, Looijenga L, Tytgat GAM, Ylstra B, Molenaar JJ, Dolman MEM, van Hooff SR.   +14 more
europepmc   +3 more sources

EPEN-10. SPINAL EPENDYMOMA WITH MYCN-AMPLIFICATION – A DISEASE OF CHILDHOOD AND YOUNG ADULTHOOD WITH DISMAL PROGNOSIS [PDF]

Neuro Oncol, 2023
David R. Ghasemi, Martin Sill, Konstantin Okonechnikov, Margaret Shatara, Stephen Yip, Zita Reisz, Karl-Heinz Plate, David Scheie, Benedikte Hasselbalch, Hildegard Dohmen, Amel Chaouch, Nada Jabado, Wilfred F.A. den Dunnen, Pieter Wesseling, Stefan Fröhling, Andrew M. Donson, David Capper, Ulrich Schüller, Stefan M. Pfister, David Reuß, Kristian W. Pajtler   +20 more
europepmc   +3 more sources