Nature Communications, 2021 Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the ...
Zsuzsanna Nagy +15 more
doaj +1 more source
Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival [PDF]
, 2009 MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of cancer, including neuroblastoma, an often fatal paediatric cancer originating from precursor cells
Alcock, L. +15 more
core +4 more sources
Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells [PDF]
, 2015 © 2014 The Authors. Approximately half of poor prognosis neuroblastomas (NBs) are characterized by pathognomonic MYCN gene amplification and MYCN over-expression.
Alexander Greenhough +37 more
core +5 more sources
Diagnostic Pathology, 2013 Background Amplification of MYCN oncogene is an established marker indicating aggressive tumor progression of neuroblastoma (NBL). But copy number analyses of MYCN gene in ganglioneuroblastoma (GNBL) and ganglioneuroma(GN) is poorly described in the ...
Wang Miao +4 more
doaj +1 more source
VLT observations of the asymmetric Etched Hourglass Nebula, MyCn 18 [PDF]
A&A 569, A50 (2014), 2014 Context. The mechanisms that form extreme bipolar planetary nebulae remain unclear. Aims. The physical properties, structure, and dynamics of the bipolar planetary nebula, MyCn 18, are investigated in detail with the aim of understanding the shaping mechanism and evolutionary history of this object. Methods.
arxiv +1 more source
Combining chromosomal arm status and significantly aberrant genomic locations reveals new cancer subtypes [PDF]
, 2008 Many types of tumors exhibit chromosomal losses or gains, as well as local amplifications and deletions. Within any given tumor type, sample specific amplifications and deletionsare also observed.
Domany, Eytan +4 more
core +4 more sources
Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells [PDF]
, 2015 This research was originally published in Journal of Biological Chemistry. Olesya Chayka, Cosimo Walter D’Acunto, Odette Middleton, Maryam Arab, and Arturo Sala.
Arab, M +4 more
core +1 more source
Formation of Double Rings Around Evolved Stars [PDF]
Astrophys.J. 577 (2002) 839-844, 2002 I propose a scenario for the formation of double-ring systems, as observed in some planetary nebulae and in the outer rings of SN 1987A. In this scenario, two jets, one jet on each side of the equatorial plane, expand into a thin, dense shell. Such a flow is expected in binary systems where the mass-losing primary undergoes an impulsive mass loss ...
arxiv +1 more source
Downregulation of MYCN through PI3K inhibition in mouse models of pediatric neural cancer
Frontiers in Oncology, 2015 The MYCN proto-oncogene is associated with poor outcome across a broad range of pediatric tumors. While amplification of MYCN drives subsets of high risk neuroblastoma and medulloblastoma, dysregulation of MYCN in medulloblastoma (in the absence of ...
Tene Aneka Cage +13 more
doaj +1 more source
A novel and universal method for microRNA RT-qPCR data normalization [PDF]
, 2009 Gene expression analysis of microRNA molecules is becoming increasingly important. In this study we assess the use of the mean expression value of all expressed microRNAs in a given sample as a normalization factor for microRNA real-time quantitative PCR
De Weer, An +6 more
core +2 more sources