Results 81 to 90 of about 272,512 (195)
A 67‐year‐old man with a spinal extramedullary mass
Brain Pathology, EarlyView.
Marcella Callea +3 more
wiley +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
EBioMedicine, 2015 Dysregulated expression of MYC family genes is a hallmark of many malignancies. Unfortunately, these proteins are not amenable to blockade by small molecules or protein-based therapeutic agents.
Long Gu +10 more
doaj +1 more source
Biological Reviews, Volume 101, Issue 5, Page 2103-2118, October 2026.ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu +12 more
wiley +1 more source
Pheno-MYCN maps the morphological footprint of MYCN amplification in paediatric neuroblastoma
MYCN amplification has long been a prognostic marker in paediatric neuroblastoma, yet is typically assayed in bulk, alongside rather than within the heterogeneous tissue architecture pathologists assess.
Olga Fourkioti +7 more
core +1 more source
, 2008 [[abstract]]Amplification of the MYCN oncogene in neuroblastomas is generally associated with a more aggressive clinical course. Recently, I of the minichromosome maintenance proteins, MCM7, was found to be a direct target of the MYCN transcription ...
Tsai, HY; Hsi, BL; Hung, IJ; Yang, CP; Lin, JN; Chen, JC; Tsai, SF; Huang, SF
core +1 more source
, 2013 Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor
Weiss, William A, Huang, Miller
core +1 more source
MYCN amplification in neuroblastoma: A paradigm for the clinical use of an oncogene
Pathology & Oncology Research, 1997 Increase of the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells. The presence of amplified cellular oncogenes is usually signalled by conspicuous chromosomal abnormalities, "double minutes" (DMs) or "homogeneously staining chromsomal regions" (HSRs).
openaire +2 more sources
International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.High PSEN1 expression identifies a favourable‐prognosis state in SHH α medulloblastoma and is associated with a reproducible transcriptional programme related to cellular homeostasis and development. Its broad expression during cerebellar development and across paediatric brain tumours suggests that its prognostic significance reflects the specific ...
Julia Vanini +6 more
wiley +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko +19 more
wiley +1 more source