Results 81 to 90 of about 289,170 (184)
Brain Pathology, EarlyView.In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles +15 more
wiley +1 more source
Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines
BMC Cancer, 2008 Background Many cancers preferentially meet their energy requirements through the glycolytic pathway rather than via the more efficient oxidative phosphorylation pathway. It is thought that this is an important adaptation in cancer malignancy.
Hatzinisiriou Irene +4 more
doaj +1 more source
Brain Pathology, EarlyView.A practical formalin‐fixed, paraffin‐embedded (FFPE)‐based molecular workflow integrating pathology, immunohistochemistry, and genomic profiling provides clinically meaningful subgroup classification of pediatric medulloblastoma and expands molecular evidence from an underrepresented Central Asian population. Abstract Medulloblastoma is the most common
Aidos Bolatov +9 more
wiley +1 more source
Olfactory domain family protein 3 promotes the proliferation of MYCN-amplified neuroblastoma cell lines in vitro [PDF]
Jichu yixue yu linchuangObjective To explore the function of olfactomedin domain family protein 3 (OLFM3) in neuroblastoma (NB). Methods The relationship between the expression of OLFM3 mRNA and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog(MYCN ...
ZHANG Yao, ZHANG Xuan, JIA Anna, ZHAN Shijia, GUO Jinxin, CHANG Yan, GUO Yongli
doaj +1 more source
Cancer Science, EarlyView.Spatial transcriptomic profiling of SCLC revealed marked intratumoral heterogeneity, including coexisting neuroendocrine and non‐neuroendocrine states and spatially heterogeneous hypoxia, and identified an MMP12+ macrophage population enriched at hypoxic and necrotic tumor interfaces.
Naozane Nomura +15 more
wiley +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
A 67‐year‐old man with a spinal extramedullary mass
Brain Pathology, EarlyView.
Marcella Callea +3 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.ABSTRACT Background In patients with neuroblastoma (NB), skeletal muscle atrophy is a key factor linked to poor survival and decreased long‐term quality of life. Nevertheless, there are still insufficient therapeutic methods that work, and the underlying mechanisms remain unclear.
Jianwei Lin +5 more
wiley +1 more source
MYCN amplification in neuroblastoma: A paradigm for the clinical use of an oncogene
Pathology & Oncology Research, 1997 Increase of the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells. The presence of amplified cellular oncogenes is usually signalled by conspicuous chromosomal abnormalities, "double minutes" (DMs) or "homogeneously staining chromsomal regions" (HSRs).
openaire +2 more sources