Results 101 to 110 of about 289,170 (184)

MYCN oncogene amplification in neuroblastoma is associated with worse prognosis, except in stage 4s: the Italian experience with 295 children.

, 1997
PURPOSE To evaluate the prognostic role of MYCN oncogene amplification in children with neuroblastoma. PATIENTS AND METHODS Of 694 children (age, 0 to 15 years) with previously untreated neuroblastoma, 295 (42%) were evaluated at diagnosis for MYCN gene ...
P Perri, G P Tonini, F Casale, A Pession, D Rogers, K Mazzocco, L Cordero di Montezemolo, P Scaruffi, L Boni, G Basso, C Milanaccio, P Bruzzi, N Marchese, C Lo Cunsolo, A Iolascon, B De Bernardi, M Conte   +16 more
core   +1 more source

Correlation of MYCN amplification with MCM7 protein expression in neuroblastomas: A chromogenic in situ hybridization study in paraffin sections

, 2008
[[abstract]]Amplification of the MYCN oncogene in neuroblastomas is generally associated with a more aggressive clinical course. Recently, I of the minichromosome maintenance proteins, MCM7, was found to be a direct target of the MYCN transcription ...
Tsai, HY; Hsi, BL; Hung, IJ; Yang, CP; Lin, JN; Chen, JC; Tsai, SF; Huang, SF
core   +1 more source

Heterogeneity of the MYCN oncogene in neuroblastoma

, 2009
PURPOSE: MYCN amplification is an important therapy-stratifying marker in neuroblastoma. Fluorescence in situ hybridization with signal detection on the single-cell level allows a critical judgement of MYCN intratumoral heterogeneity. EXPERIMENTAL DESIGN:
Christiansen, H, Niggli, F, Hero, B, Boensch, M, Stegmaier, S, Betts, D, Berthold, F, Spitz, R, Theissen, J, Simon, T, Westermann, F, Schwab, M, Schilling, F   +12 more
core   +1 more source

Mycn and Erbb2 amplification and expression results for HH-16 cl.2/1 and HH-16.cl.4.

, 2012
Mycn and Erbb2 amplification results were calculated as the Mycn/RNO6 and Erbb2/RNO 10 ratios, respectively (values between brackets represent the percentage of analyzed cells showing that result). Expression levels were accessed by RT-qPCR and RNA FISH (
Raquel Chaves (188644), Sandra Louzada (188636), Filomena Adega (188641)   +2 more
core   +1 more source

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures. [PDF]

Nat Commun, 2023
Schoof M, Godbole S, Albert TK, Dottermusch M, Walter C, Ballast A, Qin N, Olivera MB, Göbel C, Neyazi S, Holdhof D, Kresbach C, Peter LS, Epplen GD, Thaden V, Spohn M, Blattner-Johnson M, Modemann F, Mynarek M, Rutkowski S, Sill M, Varghese J, Afflerbach AK, Eckhardt A, Münter D, Verma A, Struve N, Jones DTW, Remke M, Neumann JE, Kerl K, Schüller U.   +31 more
europepmc   +1 more source

Effect of MYCN Amplification on Tumor Response and Recurrence in Patients With Stage IV Neuroblastoma

PURPOSE – MYCN amplification (MYCN-A) is an important prognostic marker in neuroblastoma. However, the impact of MYCN-A in patients with metastasized high-risk neuroblastoma during the course of disease remains unclear.
Researchgr. Nucleaire Geneeskunde, Tytgat, Godelieve A.M., Fiocco, Marta, Matser, Yvette A.H., Langenberg, Karin P.S., Kraal, Kathelijne C.J.M., Genetica, Dierselhuis, Miranda P., van Eijkelenburg, Natasha K.A., Onderzoek Beeld, van Kuilenburg, André B.P., Samim, Atia, van Grotel, Martine, van Noesel, Max M., van Liempt, Lotte M., Molenaar, Jan, Cancer   +16 more
core  

Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell-derived neural crest cells. [PDF]

Cancer Sci, 2023
Mukae K, Takenobu H, Endo Y, Haruta M, Shi T, Satoh S, Ohira M, Funato M, Toguchida J, Osafune K, Nakahata T, Kanda H, Kamijo T.   +12 more
europepmc   +1 more source

Upregulated detection of MYCN and EIF5A2 in UACC-1598.

, 2012
DNA amplification level of MYCN and EIF5A2 were evaluated by PCR(A). Expression of MYCN and EIF5A2 in UACC-1598 cells were determined by RT-PCR (B) and western blot analysis (C). Cells isolated from normal ovarian tissues were used as control.
Zheng Liu (28397), Feng Chen (25347), Ki-Young Lee (185268), Xinying Ma (185246), Yang Yu (4292), Jesusa Rosales (185262), Yan Jin (143500), Songbin Fu (45499), Jing Bai (185253), Yihui Fan (185250), Wei Cao (50866)   +10 more
core   +1 more source

Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology

npj Precision Oncology
A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained whole slide ...
Siddhi Ramesh, Emma Dyer, Monica Pomaville, Kristina Doytcheva, James Dolezal, Sara Kochanny, Rachel Terhaar, Casey J. Mehrhoff, Kritika Patel, Jacob Brewer, Benjamin Kusswurm, Arlene Naranjo, Hiroyuki Shimada, Nicole A. Cipriani, Aliya N. Husain, Peter Pytel, Elizabeth A. Sokol, Susan L. Cohn, Rani E. George, Alexander T. Pearson, Mark A. Applebaum   +20 more
doaj   +1 more source

Impact of 11q Loss of Heterozygosity Status on the Response of High-Risk Neuroblastoma With MYCN Amplification to Neoadjuvant Chemotherapy. [PDF]

Front Pediatr, 2022
Lu XY, Qu LJ, Duan XL, Zuo W, Sai K, Rui G, Gong XF, Ding YB, Gao Q.   +8 more
europepmc   +1 more source