Results 111 to 120 of about 289,170 (184)

Impact of Genomic and Clinical Factors on Outcome of Children ≥18 Months of Age with Stage 3 Neuroblastoma with Unfavorable Histology and without MYCN Amplification: A Children's Oncology Group (COG) Report. [PDF]

Clin Cancer Res, 2023
Pinto N, Naranjo A, Ding X, Zhang FF, Hibbitts E, Kennedy R, Tibbetts R, Wong-Michalak S, Craig DW, Manojlovic Z, Hogarty MD, Kreissman S, Bagatell R, Irwin MS, Park JR, Asgharzadeh S.   +15 more
europepmc   +1 more source

High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

Cell Reports
Summary: MYCN amplification, a characteristic of aggressive neuroblastoma, presents therapeutic challenges. This study uncovered the potential effects of a fructose metabolite, acetate, on the transcriptional regulation of MYCN expression, which is still
Wenquan Hu, Xiang Wang, Zhi Fang, Jing Zhang, Munichandra Babu Tirumalasetty, Qing Robert Miao   +5 more
doaj   +1 more source

Identification of a Five-Gene Signature Derived From MYCN Amplification and Establishment of a Nomogram for Predicting the Prognosis of Neuroblastoma. [PDF]

Front Mol Biosci, 2021
Xia Y, Li X, Tian X, Zhao Q.
europepmc   +1 more source

Supplementary Material for: Integrated Cytogenetic and High-Resolution Array CGH Analysis of Genomic Alterations Associated with MYCN Amplification

, 2017
Amplification of oncogenes and closely linked flanking genes is common in some types of cancer and can be associated with complex chromosome rearrangements and/or co-amplification of non-syntenic chromosomal regions. To better understand the etiology and
Pandita A. (4125685), Prasad M. (4125694), Squire J.A. (4122370), Graham C. (4125691), Paderova J. (4125676), Zielenska M. (4122364), Marrano P. (4125679), Bayani J. (4125682), Barrett M. (4125688)   +8 more
core   +1 more source

A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma

Communications Biology
Retinoblastoma are childhood eye tumors arising from retinal precursor cells. Two distinct retinoblastoma subtypes with different clinical behavior have been described based on gene expression and methylation profiling.
Tatsiana Ryl, Elena Afanasyeva, Till Hartmann, Melanie Schwermer, Markus Schneider, Christopher Schröder, Maren Wagemanns, Arthur Bister, Deniz Kanber, Laura Steenpass, Kathrin Schramm, Barbara Jones, David T. W. Jones, Eva Biewald, Kathy Astrahantseff, Helmut Hanenberg, Sven Rahmann, Dietmar R. Lohmann, Alexander Schramm, Petra Ketteler   +19 more
doaj   +1 more source

Prediction of MYCN Amplification, 1p and 11q Aberrations in Pediatric Neuroblastoma via Pre-therapy 18F-FDG PET/CT Radiomics. [PDF]

Front Med (Lausanne), 2022
Qian L, Yang S, Zhang S, Qin H, Wang W, Kan Y, Liu L, Li J, Zhang H, Yang J.   +9 more
europepmc   +1 more source

Malignant gliomas with H3F3A G34R mutation or MYCN amplification in pediatric patients with Li Fraumeni syndrome. [PDF]

Acta Neuropathol, 2021
Schoof M, Kordes U, Volk AE, Al-Kershi S, Kresbach C, Schüller U.   +5 more
europepmc   +1 more source

CT-Based Radiomics Signature With Machine Learning Predicts MYCN Amplification in Pediatric Abdominal Neuroblastoma. [PDF]

Front Oncol, 2021
Chen X, Wang H, Huang K, Liu H, Ding H, Zhang L, Zhang T, Yu W, He L.   +8 more
europepmc   +1 more source

Absence of MYCN Gene Amplification [PDF]

, 2020
openaire   +1 more source

MYCN amplification and 17q in neuroblastoma: Evidence for structural association

MYCN oncogene amplification in neuroblastoma is statistically associated with gain of chromosome segment 17q21-qter. In neuroblastoma cell lines and primary tumors with MYCN amplification in the form of homogeneously staining regions (hsrs ...
O'Neill S; Lastowska M; Ekstrom L; Roberts P; Brodeur GM; Kees UR; Schwab M; Bown N
core   +4 more sources