Results 121 to 130 of about 272,512 (195)

High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

Cell Reports
Summary: MYCN amplification, a characteristic of aggressive neuroblastoma, presents therapeutic challenges. This study uncovered the potential effects of a fructose metabolite, acetate, on the transcriptional regulation of MYCN expression, which is still
Wenquan Hu, Xiang Wang, Zhi Fang, Jing Zhang, Munichandra Babu Tirumalasetty, Qing Robert Miao   +5 more
doaj   +1 more source

Identification of a Five-Gene Signature Derived From MYCN Amplification and Establishment of a Nomogram for Predicting the Prognosis of Neuroblastoma. [PDF]

Front Mol Biosci, 2021
Xia Y, Li X, Tian X, Zhao Q.
europepmc   +1 more source

A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma

Communications Biology
Retinoblastoma are childhood eye tumors arising from retinal precursor cells. Two distinct retinoblastoma subtypes with different clinical behavior have been described based on gene expression and methylation profiling.
Tatsiana Ryl, Elena Afanasyeva, Till Hartmann, Melanie Schwermer, Markus Schneider, Christopher Schröder, Maren Wagemanns, Arthur Bister, Deniz Kanber, Laura Steenpass, Kathrin Schramm, Barbara Jones, David T. W. Jones, Eva Biewald, Kathy Astrahantseff, Helmut Hanenberg, Sven Rahmann, Dietmar R. Lohmann, Alexander Schramm, Petra Ketteler   +19 more
doaj   +1 more source

Prediction of MYCN Amplification, 1p and 11q Aberrations in Pediatric Neuroblastoma via Pre-therapy 18F-FDG PET/CT Radiomics. [PDF]

Front Med (Lausanne), 2022
Qian L, Yang S, Zhang S, Qin H, Wang W, Kan Y, Liu L, Li J, Zhang H, Yang J.   +9 more
europepmc   +1 more source

Malignant gliomas with H3F3A G34R mutation or MYCN amplification in pediatric patients with Li Fraumeni syndrome. [PDF]

Acta Neuropathol, 2021
Schoof M, Kordes U, Volk AE, Al-Kershi S, Kresbach C, Schüller U.   +5 more
europepmc   +1 more source

CT-Based Radiomics Signature With Machine Learning Predicts MYCN Amplification in Pediatric Abdominal Neuroblastoma. [PDF]

Front Oncol, 2021
Chen X, Wang H, Huang K, Liu H, Ding H, Zhang L, Zhang T, Yu W, He L.   +8 more
europepmc   +1 more source

Absence of MYCN Gene Amplification [PDF]

, 2020
openaire   +1 more source

Gene Expression in Neuroblastoma [PDF]

, 1996
The aim of this project is to identify potential target genes (NTG's) which may be regulated by in the cell line SK-N-SH which has no amplification of theoncogene N-myc.
Said, Sohair S.S.
core  

Identification of Crucial Genes Associated With MYCN‐Driven Neuroblastoma Based on Single‐Cell Analysis and Machine Learning

Cancer Medicine
Background Neuroblastoma (NB) with MYCN amplification is strongly correlated with high‐risk stratification and poor prognosis. However, the underlying mechanisms remain incompletely understood.
Jiasi Zhang, Yichen Lei, Yaqin Wang, Wen Yu, Xiaoyan Zhao, Yongbing Zhu, Dedong Zhang, Siying Liu, Aiguo Liu   +8 more
doaj   +1 more source

Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes. [PDF]

, 2012
In this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma.
Lundberg, Gisela
core