Results 91 to 100 of about 289,170 (184)
Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.
PLoS ONE, 2014 Neuroblastoma, a tumor of the peripheral sympathetic nervous system, is the most common and deadly extracranial tumor of childhood. The majority of high-risk neuroblastoma exhibit amplification of the MYCN proto-oncogene and increased neoangiogenesis ...
Raul Calero +3 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification
, 2017 Neuroblastomas are highly invasive tumors that occur in pediatric patients and treatment of invasive disease remains a challenge. The study of cells invading in 3-dimensional (3D) hydrogels has revealed morphologically distinct modes of invasion by which
Camilla B. Mitchell (2807428) +1 more
core +1 more source
AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for ependymomas
Brain Pathology, Volume 36, Issue 6, November 2026.Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions (ADAPTR) recommendations for ependymomas in resource‐restrained settings (RL = resource level; created in BioRender). Abstract Ependymomas are uncommon primary tumors of the central nervous system (CNS) that affect both children and adults.
Laveniya Satgunaseelan +13 more
wiley +1 more source
Cancer Medicine, 2020 Background Neuroblastoma is the most common pediatric solid tumor. MYCN‐amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood.
Eleanor C. Semmes +6 more
doaj +1 more source
Relationship between histopathological features, MYCN amplification, and prognosis: A UKCCSG study
Histological sections from 231 patients with neuroblastoma were reviewed and morphological features and their relationship to age, stage, MYCN amplification (in 128 trumours by Southern analyses), and clinical outcome (based on Shimada risk grouping ...
R.E. +14 more
core +4 more sources
Neoplasia: An International Journal for Oncology ResearchBackground: In neuroblastoma MYCN amplification is associated with enhanced angiogenesis and poor survival. Mutations in the anaplastic lymphoma kinase (ALK) gene can occur with MYCN amplification, conferring a very poor prognosis.
Gilberto S. Almeida +10 more
doaj +1 more source
Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation
Cell Reports, 2017 Growing evidence suggests a major role for Src-homology-2-domain-containing phosphatase 2 (SHP2/PTPN11) in MYCN-driven high-risk neuroblastoma, although biologic confirmation and a plausible mechanism for this contribution are lacking.
Xiaoling Zhang +12 more
doaj +1 more source
, 2015 (A) Western blot analysis was performed to investigate the expression of JARID1B and α-MYCN in MYCN amplification (MNA+) and non-MYCN amplification (MNA-) NB cells. (B) The SP percentage was analyzed in MNA+ and MNA- NB cells by Hoechst staining and flow
Yung-Feng Liao (201211) +9 more
core +1 more source