Results 61 to 70 of about 3,839,668 (166)

Microbiological profile of tubercular and nontubercular empyemas and its impact on clinical outcomes: A retrospective analysis of 285 consecutively operated cases

Lung India, 2020
Background: Empyema thoracis is an entity seen across all age groups. This study aims at reporting a detailed microbiological profile of “pus and pleural tissue” in patients operated for empyema thoracis and also correlating it with perioperative ...
Mohan Venkatesh Pulle, Belal Bin Asaf, Arvind Kumar, Harsh Vardhan Puri, C L Vijay, Sukhram Bishnoi   +5 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Culture at High Density Improves the Ability of Human Macrophages to Control Mycobacterial Growth

, 2001
International audienceThe mechanisms through which granuloma formation helps control mycobacterial infection are poorly understood, but it is possible that the accumulation of macrophages at high density at sites of infection promotes the differentiation
Neio Boechat, Vladimir Pelicic, Francine Bouchonnet, Gicquel, Brigitte, Hance, Allan, J., Allan J. Hance, Bouchonnet, Francine, Marcel Bonay, Brigitte Gicquel, Grodet, Alain, Alain Grodet, Bonay, Marcel, Pelicic, V., Boechat, Neio   +13 more
core   +1 more source

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Case series: Kikuchi‐Fujimoto disease with diagnostic overlap

Rheumatology &Autoimmunity, EarlyView.
Kikuchi‐Fujimoto disease (KFD) is a rare, self‐limiting necrotizing lymphadenitis that poses significant diagnostic challenges due to its overlap with tuberculosis, systemic lupus erythematosus (SLE), and malignancy. We present four cases highlighting distinct diagnostic complexities: KFD mimicking tuberculosis with concomitant latent TB infection and ...
Ecem Kalemoglu, Ming Zheng, Danny Arias, Andreina M. Paulino, Aisha Niaz, James Devlin, Valentin Marian   +6 more
wiley   +1 more source

Diagnostic accuracy of chip hybridization from formalin-fixed paraffin embedded bioptic specimens in a cohort with predominantly extrapulmonary mycobacterial disease

BMC Microbiology
Introduction Extrapulmonary tuberculosis (TB) and non-tuberculous mycobacterial (NTM) disease remain a diagnostic challenge and conventional methods such as mycobacterial culture or molecular methods (e.g.
Ria Winkelmann, Belana Blasczok, Melanie Winter, Peter Wild, Maria J.G.T. Vehreschild, Volkhard A.J. Kempf, Thomas A. Wichelhaus, Raja Idris, Nils Wetzstein   +8 more
doaj   +1 more source

Mycobacterium intracellulare M.i.198—A Promising Strain for Studying Pathogenesis of Nontuberculous Mycobacterial Pulmonary Disease (NTM‐PD)

Microbiology and Immunology, EarlyView.
ABSTRACT In this review, we introduce a promising strain for studying pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM‐PD), Mycobacterium intracellulare M.i.198. M.i.198 was isolated from a patient with progressive Mycobacterium avium‐intracellulare complex pulmonary disease (MAC‐PD) in whom surgical operation was required to ...
Yoshitaka Tateishi, Ryoji Maekura, Yukiko Nishiuchi, Sohkichi Matsumoto   +3 more
wiley   +1 more source

Identification and characterisation of endogenous inducible promoters in Mycobacterium tuberculosis [PDF]

, 2010
PhDMycobacterium tuberculosis is one of the world’s most devastating pathogens. Despite completion of the genome sequence in 1998, research progress has been hampered by a lack of genetic tools and the difficulty of working with the organism. Existing
Schuessler, Dorothée Laura
core   +4 more sources

Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024

Alimentary Pharmacology &Therapeutics, EarlyView.
In this nationwide study of patients with inflammatory bowel disease, TNF inhibitor use was associated with higher bloodstream infection rates, whereas vedolizumab and ustekinumab was not. Associations differed by pathogen species, and concomitant glucocorticoid use was associated with higher infection rates.
Cæcilie Leding, Alessandra Meddis, Jon Gitz Holler, Johan Burisch, Thomas Benfield   +4 more
wiley   +1 more source

Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide.

, 2008
Mycobacterium tuberculosis is a facultative intracellular pathogen that inhibits phagosome maturation in macrophages thereby securing survival and growth.
Oschkinat, Hartmut, Stefan H. E. Kaufmann, Kaufmann, Stefan H. E., Albert Haas, Enders, Jana, Jana Enders, Hartmut Oschkinat, Axelrod, Sofia, Brigitte Schlegel, Kaufmann, Stefan HE, Ulrich E. Schaible, Volker Brinkmann, Brinkmann, Volker, Schaible, Ulrich E, Haas, Albert, Schaible, Ulrich E., Sofia Axelrod, Schlegel, Brigitte   +17 more
core   +1 more source