Results 31 to 40 of about 106,966 (124)

DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages

Cells, 2023
Damage-Regulated Autophagy Modulator 1 (DRAM1) is an infection-inducible membrane protein, whose function in the immune response is incompletely understood.
Adrianna Banducci-Karp, Jiajun Xie, Sem A. G. Engels, Christos Sarantaris, Patrick van Hage, Monica Varela, Annemarie H. Meijer, Michiel van der Vaart   +7 more
doaj   +1 more source

Exposure Pathways of Nontuberculous Mycobacteria Through Soil, Streams, and Groundwater, Hawai'i, USA

GeoHealth, 2021
Although uncommon, nontuberculous mycobacterial (NTM) pulmonary infection in the Hawaiian Islands has a relatively high incidence and mortality compared to the mainland U.S.
Stephen T. Nelson, Schuyler Robinson, Kevin Rey, Leeza Brown, Norm Jones, Stephanie N. Dawrs, Ravleen Virdi, Grant J. Norton, L. Elaine Epperson, Nabeeh A. Hasan, Edward D. Chan, Michael Strong, Jennifer R. Honda   +12 more
doaj   +1 more source

Characteristics and diseases associations of tuberculosis in lupus: A retrospective single-center analysis

Indian Journal of Rheumatology, 2022
Objective: The objective of this study is to identify factors associated with active tuberculosis (TB) in patients with systemic lupus erythematosus (SLE) and to study the impact of TB on SLE disease activity. Methodology: We screened case records of 643
Dunga Sai Kumar, Sanket Ishwarbhai Shah, Chengappa Kavadichanda, Aishwarya Gopal, Prakash Babu Narasimhan, Vir Singh Negi   +5 more
doaj   +1 more source

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA

mBio, 2019
A defining characteristic of treating tuberculosis is the need for prolonged administration of multiple drugs. This may be due in part to subpopulations of slowly replicating or nonreplicating Mycobacterium tuberculosis bacilli exhibiting phenotypic ...
Landys Lopez Quezada, Sandra Silve, Mark Kelinske, Amir Liba, Constantino Diaz Gonzalez, Martin Kotev, Laurent Goullieux, Stephanie Sans, Christine Roubert, Sophie Lagrange, Eric Bacqué, Cedric Couturier, Alain Pellet, Isabelle Blanc, Marlène Ferron, Fabrice Debu, Kelin Li, Jeffrey Aubé, Julia Roberts, David Little, Yan Ling, Jun Zhang, Ben Gold, Carl Nathan   +23 more
doaj   +1 more source

Early Drug Development and Evaluation of Putative Antitubercular Compounds in the -Omics Era

Frontiers in Microbiology, 2021
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. According to the WHO, the disease is one of the top 10 causes of death of people worldwide.
Alina Minias, Lidia Żukowska, Lidia Żukowska, Ewelina Lechowicz, Ewelina Lechowicz, Filip Gąsior, Filip Gąsior, Agnieszka Knast, Agnieszka Knast, Sabina Podlewska, Sabina Podlewska, Daria Zygała, Daria Zygała, Jarosław Dziadek   +13 more
doaj   +1 more source

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

Beilstein Journal of Nanotechnology, 2020
A number of bacterial glycans are specific markers for the detection and the serological identification of microorganisms and are also widely used as antigenic components of vaccines.
Gennady L. Burygin, Polina I. Abronina, Nikita M. Podvalnyy, Sergey A. Staroverov, Leonid O. Kononov, Lev A. Dykman   +5 more
doaj   +1 more source

Mycobacterium tuberculosis is less likely to acquire pathogenic mutations during latent infection than during active disease

Microbiology Spectrum
Most people infected with Mycobacterium tuberculosis (Mtb) are believed to be in a state of latent tuberculosis (TB) infection (LTBI). Although LTBI is asymptomatic and not infectious, there is a risk of developing active disease even decades after ...
Asami Osugi, Aki Tamaru, Takashi Yoshiyama, Tomotada Iwamoto, Satoshi Mitarai, Yoshiro Murase   +5 more
doaj   +1 more source

Structural Properties of an S-system Model of Mycobacterium Tuberculosis Gene Regulation [PDF]

arXiv, 2020
Magombedze and Mulder in 2013 studied the gene regulatory system of Mycobacterium Tuberculosis (Mtb) by partitioning this into three subsystems based on putative gene function and role in dormancy/latency development. Each subsystem, in the form of S-system, is represented by an embedded chemical reaction network (CRN), defined by a species subset and ...
arxiv  

Deciphering a Sleeping Pathogen: Uncovering Novel Transcriptional Regulators of Hypoxia-Induced Dormancy in Mycobacterium Tuberculosis [PDF]

arXiv, 2023
Along the pathogenesis of Mycobacterium Tuberculosis (MTB), hypoxia-induced dormancy is a process involving the oxygen-depleted environment encountered inside the lung granuloma, where bacilli enter a viable, non-replicating state termed as latency. Affecting nearly two billion people, latent TB can linger in the host for indefinite periods of time ...
arxiv  

Green synthesis of silver nanoparticles using Curcuma longa flower extract and antibacterial activity [PDF]

arXiv, 2023
Silver nanoparticles (AgNP's) possess inherent biological potentials that have obliged an alternative, eco-friendly, sustainable approach to "Green Synthesis." In the present study, we synthesized Green Silver Nanoparticles (GAgNP's) using Curcuma longa L. (C. longa) flower extract as a reducing and capping agent.
arxiv