Results 51 to 60 of about 302,132 (299)

Exploring clues for wide variations in COVID-19 fatality rates among countries

MGM Journal of Medical Sciences, 2022
COVID-19 flu has been the worst pandemic on earth in more than a century and has thus far claimed more than six million lives worldwide. As of 19th March 2022, there were 57 major countries where one million or more COVID-19cases were registered, and the
Prasanta Kumar Ghosh
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians [PDF]

, 2003
The naturally mummified remains of a mother and two daughters found in an 18th century Hungarian crypt were analysed, using multiple molecular genetic techniques to examine the epidemiology and evolution of tuberculosis.
Spigelman, Mark, Fletcher, H.A., van der Zanden, AG, Taylor, GM, Fletcher, Helen A, Donoghue, H.D., van der Zanden, AGM, Donoghue, HD, Fletcher, HA, Spigelman, M, Taylor, G.M., Spigelman, M., Taylor, G Michael, van der Zanden, A.G.M., Donoghue, Helen D, Fletcher, Helen, van der Zanden, Adri GM   +16 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase. [PDF]

, 2015
(S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H37Rv.
Mortazavi, Parisa Nakhostin, Munshi, T, Bhakta, S, Maitra, A, Cuca, L.E., Pesnot, T, Pesnot, T., Hailes, HC, Angell, R, Barrera, DA, Needham, D, Hailes, H.C., Bhakta, Sanjib, Davies, H.M., Gershater, MC, Davies, HM, Barrera, D.A., Evangelopoulos, Dimitrios, Cuca, LE, McMahon, E, Maitra, Arundhati, Redmond, J.M., Ward, J.M., Evangelopoulos, D, Mortazavi, PN, Munshi, Tulika, Gershater, M.C., Ward, JM, Lamming, E.D., Redmond, JM, McMahon, E., Angell, R., Guzman, JD, Guzman, Juan D., Needham, D., Lamming, ED   +35 more
core   +1 more source

Assessing the accuracy of the updated Fujifilm SILVAMP TB LAM II assay between lot numbers

IJTLD Open
BACKGROUND: The Fujifilm SILVAMP TB LAM (FujiLAM) assay, a point-of-care test detecting urine-based lipoarabinomannans, has demonstrated notable diagnostic accuracy for TB. However, FujiLAM exhibits lot-to-lot variability, limiting its clinical use.
K. Chikamatsu, Y. Shimomura, A. Osugi, S. Mitarai   +3 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease. [PDF]

, 2014
BACKGROUND Buruli ulcer (BU) is a slowly progressing, necrotising disease of the skin caused by infection with Mycobacterium ulcerans. Non-ulcerative manifestations are nodules, plaques and oedema, which may progress to ulceration of large parts of ...
Miriam Bolz, Bolz, Miriam, Gerd Pluschke, Gert Zimmer, Meret E Ricklin, Marie-Thérèse Ruf, Ruf, Marie-Thérèse, Ricklin, Meret E, Ruggli, Nicolas, Zimmer, Gert, Ricklin, Meret E., Nicolas Ruggli, Pluschke, Gerd   +12 more
core   +1 more source

The Dream of a Mycobacterium

Microbiology Spectrum, 2019
ABSTRACT How do mycobacteria divide? Cell division has been studied extensively in the model rod-shaped bacteria Escherichia coli and Bacillus subtilis , but much less is understood about cell division in mycobacteria, a genus that includes the major human pathogens M ...
Catherine, Baranowski, E Hesper, Rego, Eric J, Rubin   +2 more
openaire   +2 more sources