Infection control in the brain and the eye
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester +2 more
wiley +1 more source
The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley +1 more source
Complete genome sequence of MP2445, a mycobacteriophage that can infect <i>Mycobacterium bovis</i> BCG and <i>Mycobacterium fortuitum</i>. [PDF]
Zhu X +8 more
europepmc +1 more source
Immune System Development—Pro Tips for Paediatricians
ABSTRACT There are many misconceptions about the immune system in children, its impact on infectious disease susceptibility and its role in the rapidly increasing rates of immune mediated diseases in industrialized societies. In this mini review, I will discuss common believes and the data supporting or countering such believes, with a focus on ...
Petter Brodin
wiley +1 more source
Performance and Cost-Efficiency of an MPT64 Assay for Detecting <i>Mycobacterium tuberculosis</i> Complex in a Setting With Frequent Nontuberculous Mycobacteria Isolation. [PDF]
Yu HJ +7 more
europepmc +1 more source
Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan +8 more
wiley +1 more source
Mendelian susceptibility to mycobacterial disease: IFN-γ-driven immunity collapse underlies heterogeneous infections. [PDF]
Qian M +6 more
europepmc +1 more source
Genomic comparison of clinical strains of <i>Mycobacterium shinjukuense</i> in Japan reveals low diversity and stable genome structures. [PDF]
Wada T +8 more
europepmc +1 more source
Improving the use of expert opinion in disease risk analysis for conservation translocations
Abstract Conservation translocations are subject to considerable uncertainty and risk, of which disease is one of the most recognized. To address disease risks, several protocols for qualitative disease risk analysis (qDRA) exist and are used for responsible conservation translocation planning.
John G. Ewen +13 more
wiley +1 more source
Identification and drug resistance profiling of <i>Mycobacterium orygis</i> from an African elephant using whole-genome sequencing. [PDF]
Ghayas H +14 more
europepmc +1 more source

