Results 81 to 90 of about 302,132 (299)

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

Beilstein Journal of Nanotechnology, 2020
A number of bacterial glycans are specific markers for the detection and the serological identification of microorganisms and are also widely used as antigenic components of vaccines.
Gennady L. Burygin, Polina I. Abronina, Nikita M. Podvalnyy, Sergey A. Staroverov, Leonid O. Kononov, Lev A. Dykman   +5 more
doaj   +1 more source

In search of a combined brucellosis and tuberculosis vaccine for cattle

Austral Journal of Veterinary Sciences, 2021
Bovine brucellosis is caused by Brucella abortus. The bacterial pathogen causes economic losses because it induces abortion in cattle. Vaccination of calves with live B.
Gerhardt G. Schurig, Stephen M. Boyle, Hamzeh Al Qublan, Nammalwar Sriranganathan   +3 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Advances in Cardiovascular Disease Lipid Research Can Provide Novel Insights Into Mycobacterial Pathogenesis

Frontiers in Cellular and Infection Microbiology, 2019
Cardiovascular disease (CVD) is the leading cause of death in industrialized nations and an emerging health problem in the developing world. Systemic inflammatory processes associated with alterations in lipid metabolism are a major contributing factor ...
Shyamala Thirunavukkarasu, Shabaana A. Khader   +1 more
doaj   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Development of a temperature-switch PCR-based SNP typing method for Mycobacterium ulcerans [PDF]

, 2012
Mycobacterium ulcerans (M. ulcerans), the causative agent of the devastating skin disease Buruli ulcer (BU), is characterized by an extremely low level of genetic diversity.
Danso Emelia, Röltgen, K., Gerd Pluschke, Pluschke Gerd, Yeboah-Manu, D., Katharina Röltgen, Dorothy Yeboah-Manu (120059), Gerd Pluschke (7855), Emelia Danso, Katharina Röltgen (120045), Danso, E., Pluschke, G., Kobina Assan-Ampah, Emelia Danso (120054), Dorothy Yeboah-Manu, Kobina Assan-Ampah (120049), Yeboah-Manu Dorothy, Assan-Ampah Kobina, Assan-Ampah, K., Röltgen Katharina   +19 more
core   +1 more source

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

Construction of a severely attenuated mutant of Mycobacterium tuberculosis for reducing risk to laboratory workers [PDF]

, 2008
The ability to construct defined deletions of Mycobacterium tuberculosis has allowed many genes involved in virulence to be identified. Deletion of nutritional genes leads to varying levels of attenuation, presumably reflecting the need for a particular ...
Williams, A, Williams, Ann, Clark, S, Clark, Simon, Smith, D, Hatch, Graham, Movahedzadeh, F, Stoker, N G, Movahedzadeh, Farahnaz, Bacon, Joanna, Parish, T, LSHTM, Ten Bokum, A M C, Parish, Tanya, Hatch, G, Smith, Debbie, HPA, Bacon, J, ten Bokum, Annemieke, Stoker, Neil   +19 more
core   +1 more source

Mycobacterial Spindle Cell Pseudotumor Presenting as a Pancreatic Head Mass: A Case Report

Pathogens
Mycobacterial spindle cell pseudotumors (MSCPs) are rare lesions characterized by the proliferation of spindle-shaped histiocytes caused by mycobacterial infections.
Frank A Cusimano, Tara Herrera, Douglas Brust, Elizabeth Montgomery, Sunil Amin, Folusakin Ayoade   +5 more
doaj   +1 more source

Thalidomide and Phosphodiesterase 4 Inhibitors as Host Directed Therapeutics for Tuberculous Meningitis: Insights From the Rabbit Model

Frontiers in Cellular and Infection Microbiology, 2020
Tuberculous meningitis (TBM) is the most devastating form of extrapulmonary Mycobacterium tuberculosis infection in humans. Severe inflammation and extensive tissue damage drive the morbidity and mortality of this manifestation of tuberculosis (TB ...
Ranjeet Kumar, Afsal Kolloli, Pooja Singh, Christopher Vinnard, Gilla Kaplan, Selvakumar Subbian   +5 more
doaj   +1 more source