Results 101 to 110 of about 302,132 (299)

PolyTB: a genomic variation map for Mycobacterium tuberculosis [PDF]

, 2014
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second major cause of death from an infectious disease worldwide. Recent advances in DNA sequencing are leading to the ability to generate whole genome information in clinical isolates ...
Gagneux, S., Perdigão, João, McNerney, R., Glynn, Judith R., McNerney, Ruth, Preston, M., Perdigao, J., Gagneux, Sebastien, Viveiros, M., Glynn, Judith R, Guerra-Assunção, José Afonso, Glynn, J., Parkhill, J., Harris, D., Clark, T., Coll, Francesc, Viveiros, Miguel, Hill-Cawthorne, G., Hill-Cawthorn, Grant, Pain, A., Pain, Arnab, Clark, Taane G., Portugal, I., Parkhill, Julian, Preston, Mark, Drobniewski, Francis, Drobniewski, F., Portugal, Isabel, Martin, Nigel, Guerra-Assuncao, J., Harris, David, Coll, F., Clark, Taane G   +32 more
core   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Interference of Mycobacterium tuberculosis with macrophage responses [PDF]

, 2009
Tuberculosis, caused by Mycobacterium tuberculosis, has become an important health and economic burden, with more than four thousand people succumbing to the disease every day.
Pieters, J., Mueller, P., Scherr, N., Jayachandran, R.   +3 more
core  

Mycobacterium tuberculosis acg Gene Is Required for Growth and Virulence In Vivo. [PDF]

, 2011
Mycobacterium tuberculosis dosRS two-component regulatory system controls transcription of approximately 50 genes including hspX, acg and Rv2030c, in response to hypoxia and nitric oxide conditions and within macrophages and mice.
Hu, Y, Yanmin Hu, Hu Yanmin, Anthony R M Coates, Anthony R. M. Coates, Coates, AR, Coates Anthony R. M.   +6 more
core   +1 more source

Diagnóstico de meningitis tuberculosa

Acta Neurológica Colombiana, 2015
La tuberculosis continúa siendo un problema mundial de salud pública y su presentación como meningitis tuberculosa es grave, ya que ocasiona una gran parte de muertes y discapacidad.
Juan Sebastián Saavedra , Sebastián Urrego, Ángela Pérez, María Eugenia Toro   +3 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Mapping the fitness of Mycobacterium tuberculosis strains: a complex picture. [PDF]

, 2010
Acquisition of antibiotic resistance in Mycobacterium tuberculosis has been shown to incur a fitness cost; the size of which depends on the position and nature of the mutation. The frequency at which resistant M. tuberculosis strains are isolated in vivo
Gillespie, S. H., O'Sullivan, DM, T. D. McHugh, McHugh, TD, S. H. Gillespie, Gillespie, SH, O'Sullivan, D. M., McHugh, T. D., D. M. O'Sullivan   +8 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population [PDF]

, 2013
Includes abstract.Includes bibliographical references.The genome structure of Mycobacterium tuberculosis is strongly clonal, in the absence of horizontal gene transfer.
Sarkar, Rajesh
core