Results 121 to 130 of about 302,132 (299)

Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin [PDF]

, 2008
OBJECTIVES: To investigate how the SOS response, an error-prone DNA repair pathway, is expressed following subinhibitory quinolone treatment of Mycobacterium tuberculosis.
Butcher, P. D., Hinds, J., O'Sullivan, DM, Butcher, PD, Gillespie, Stephen Henry, Hinds, J, McHugh, TD, Gillespie, SH, O'Sullivan, D. M., McHugh, T. D.   +9 more
core   +1 more source

Effects of Age and Environment on Adaptive Immune Responses to Mycobacterium avium subsp. paratuberculosis (MAP) Vaccination in Dairy Goats in Relation to Paratuberculosis Control Strategies

Veterinary Sciences, 2019
Paratuberculosis infection is caused by Mycobacterium avium subsp. paratuberculosis (MAP). In the Netherlands, 75% herd level prevalence of caprine paratuberculosis has been estimated, and vaccination is the principal control strategy applied.
Ad Koets, Lars Ravesloot, Robin Ruuls, Annemieke Dinkla, Susanne Eisenberg, Karianne Lievaart-Peterson   +5 more
doaj   +1 more source

Investigation of Potent Anti-Mycobacterium tuberculosis Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis

Drug Design, Development and Therapy
Ahmed Sabt,1 Małgorzata Korycka-Machala,2 Asmaa F Kassem,3 Ninh The Son,4 Nguyen Xuan Ha,4 Anna Brzostek,2 Mohamed G Thabit,5 Malwina Kawka,6 Bożena Dziadek,6 Abdelsamed I Elshamy,1 Ahmed M Atwa,7,8 Jarosław Dziadek2 ...
Sabt A, Korycka-Machala M, Kassem AF, The Son N, Ha NX, Brzostek A, Thabit MG, Kawka M, Dziadek B, Elshamy AI, Atwa AM, Dziadek J   +11 more
doaj  

Mycobacterium marinum

Microbiology Spectrum, 2017
ABSTRACT Mycobacterium marinum is a well-known pathogenic mycobacterium for skin and soft tissue infections and is associated with fishes and water. Among nontuberculous mycobacteria (NTM), it is the leading cause of extrarespiratory human infections worldwide. In addition, there is a specific scientific interest in
Aubry, Alexandra, Mougari, Faiza, Reibel, Florence, Cambau, Emmanuelle   +3 more
openaire   +3 more sources

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Improved recovery of Mycobacterium tuberculosis from children using the microscopic observation drug susceptibility method. [PDF]

, 2006
OBJECTIVE: The diagnosis of pulmonary tuberculosis presents challenges in children, because symptoms are nonspecific, sputa are not accessible, and Mycobacterium tuberculosis cultures and smears often are negative.
Luz Caviedes, Oberhelman, Richard A, Gilman, Robert H, Giselle Soto-Castellares, Carlton Evans, Castillo, Maria E, Robert H. Gilman, Moore, David AJ, David A.J. Moore, Maria E. Castillo, Patricia Kissinger, Richard A. Oberhelman, Caviedes, Luz, Evans, Carlton, Soto-Castellares, Giselle, Kissinger, Patricia   +15 more
core   +1 more source

Predictive and prognostic properties of TB-LAM among HIV-positive patients initiating ART in Johannesburg, South Africa

The Pan African Medical Journal, 2015
While the diagnostic properties of the TB LAM urine assay (LAM) have been well-described, little is known about its predictive and prognostic properties at ART initiation in a routine clinic setting.
Alexander déElia, Denise Evans, Lynne McNamara, Rebecca Berhanu, Ian Sanne, Elisabet Lénnermark   +5 more
doaj   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Locally confined clonal complexes of Mycobacterium ulcerans in two Buruli ulcer endemic regions of Cameroon [PDF]

, 2015
Mycobacterium ulcerans is the causative agent of the necrotizing skin disease Buruli ulcer (BU), which has been reported from over 30 countries worldwide.
Miriam Bolz, Bayi, Pierre Franklin, Lamelas Cabello, Araceli, Pierre Franklin Bayi, Gerd Pluschke, Jacques C. Minyem (421866), Alphonse Um Boock (267187), Simon R. Harris (124597), Sarah Kerber, Um Boock, Alphonse, Vogel, Moritz, Sarah Kerber (421868), Harris, Simon R., Araceli Lamelas Cabello, Martin W. Bratschi (309715), Julian Parkhill (30393), Araceli Lamelas Cabello (750090), Daniela Brites, Moritz Vogel, Moritz Vogel (267190), Julian Parkhill, Kerber, Sarah, Bolz, Miriam, Thomas Junghanss, Miriam Bolz (309717), Alphonse Um Boock, Bratschi, Martin W., Gerd Pluschke (7855), Parkhill, Julian, Thomas Junghanss (46932), Daniela Brites (192428), Minyem, Jacques C., Martin W Bratschi, Brites, Daniela, Junghanss, Thomas, Jacques C Minyem, Simon R Harris, Pluschke, Gerd, Pierre Franklin Bayi (750089)   +38 more
core   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source