Results 131 to 140 of about 367,380 (311)

Mycobacterium marinum

open access: yesMicrobiology Spectrum, 2017
ABSTRACT Mycobacterium marinum is a well-known pathogenic mycobacterium for skin and soft tissue infections and is associated with fishes and water. Among nontuberculous mycobacteria (NTM), it is the leading cause of extrarespiratory human infections worldwide.
Aubry, Alexandra   +3 more
openaire   +3 more sources

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]

open access: yes, 2013
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
Nalini Mehta   +114 more
core   +1 more source

A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

open access: yeseLife, 2019
Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all domains of life, and its homeostasis must be regulated tightly. Here we report that a Nudix-related transcriptional factor, designated MsNrtR (MSMEG_3198), controls the de novo ...
Rongsui Gao   +5 more
doaj   +1 more source

Investigation of Potent Anti-Mycobacterium tuberculosis Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis

open access: yesDrug Design, Development and Therapy
Ahmed Sabt,1 Małgorzata Korycka-Machala,2 Asmaa F Kassem,3 Ninh The Son,4 Nguyen Xuan Ha,4 Anna Brzostek,2 Mohamed G Thabit,5 Malwina Kawka,6 Bożena Dziadek,6 Abdelsamed I Elshamy,1 Ahmed M Atwa,7,8 Jarosław Dziadek2 ...
Sabt A   +11 more
doaj  

Advances in Cardiovascular Disease Lipid Research Can Provide Novel Insights Into Mycobacterial Pathogenesis

open access: yesFrontiers in Cellular and Infection Microbiology, 2019
Cardiovascular disease (CVD) is the leading cause of death in industrialized nations and an emerging health problem in the developing world. Systemic inflammatory processes associated with alterations in lipid metabolism are a major contributing factor ...
Shyamala Thirunavukkarasu   +1 more
doaj   +1 more source

Construction of a severely attenuated mutant of Mycobacterium tuberculosis for reducing risk to laboratory workers

open access: yes, 2008
The ability to construct defined deletions of Mycobacterium tuberculosis has allowed many genes involved in virulence to be identified. Deletion of nutritional genes leads to varying levels of attenuation, presumably reflecting the need for a particular ...
Williams, A   +26 more
core   +1 more source

A sero-epidemiological approach to explore transmission of Mycobacterium ulcerans [PDF]

open access: yes, 2016
The debilitating skin disease Buruli ulcer (BU) is caused by infection with Mycobacterium ulcerans. While various hypotheses on potential reservoirs and vectors of M. ulcerans exist, the mode of transmission has remained unclear.
Yeboah-Manu, Dorothy   +54 more
core   +2 more sources

Organ‐Resolved Host Proteomic and Post‐Translational Modification Landscapes in a Mouse Model of Talaromyces marneffei Infection

open access: yesiMetaMed, EarlyView.
We presented an organ‐resolved, multiple PTM remodeling atlas of systemic T. marneffei infection, integrating quantitative proteome, phosphoproteome, ubiquitinome, acetylome, and lactylome data across the liver, lung, and spleen. The atlas delineated organ‐specific PTM signatures and a functional convergence of divergent modification types on immune ...
Wudi Wei   +16 more
wiley   +1 more source

Lectinhistochemical staining of granuloma induced by bacillus Calmette-Guerin in Piaractus mesopotamicus

open access: yesRevista Mvz Cordoba, 2013
Objetive. This study was conducted to evaluate, by means of lectinhistochemistry (LHC), the expression of carbohydrates in granulomas induced by the bacillus Calmette-Guerin (BCG) in muscle tissue of Piaractus mesopotamicus after 33 days.
Wilson G. Manrique   +7 more
doaj   +1 more source

Analysis of individualized brain–gut association networks and transcriptional patterns in major depressive disorder

open access: yesInterdisciplinary Medicine, EarlyView.
Individualized brain–gut association networks suggest potential neuropathological mechanisms in MDD and MDDSI. Multilevel brain–gut association changes involving HSV‐1 and inflammation may be relevant to MDD, whereas alterations related to insulin metabolism may play a potential role in the neuropathological mechanisms of MDDSI.
Wei Wang   +10 more
wiley   +1 more source

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