Results 141 to 150 of about 367,380 (311)
A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology
eLifeTuberculosis is once again the most fatal global infectious disease and has killed many more humans than any other pathogen. Despite the identification of Mycobacterium tuberculosis (Mtb) over 140 years ago, we have yet to control the epidemic. A central
Michaela T Reichmann +8 more
doaj +1 more source
JPGN Reports, EarlyView.Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder often presenting with extra‐intestinal manifestations (EIMs) involving the skin, joints and eyes. However, pulmonary manifestation, such as interstitial lung disease (ILD), is a rare complication, particularly in the pediatric population. We report a case of a 10‐year‐old boy,
Harshit Vachher +5 more
wiley +1 more source
Journal of Preventive, Diagnostic and Treatment Strategies in MedicineExcessive, arbitrary, self-medication, and misuse of antibiotics have caused widespread antibiotic resistance, but with the emergence of multiple antibiotic resistances, these concerns have increased.
Marjan Darbani Fouladi +3 more
doaj +1 more source
Cutaneous Rosai‐Dorfman Disease With MAP2K1 Mutation Treated With Encorafenib and Binimetinib
JEADV Clinical Practice, EarlyView.ABSTRACT Rosai‐Dorfman disease (RDD) is a rare histiocytic disorder with unifocal to multisystemic involvement. Activating mutations in the MAPK/ERK pathway can occur in up to 50% of RDD cases. We report a case of cutaneous RDD (C‐RDD) with facial and truncal lesions harboring an activating MAP2K1 (MEK1) mutation that showed a complete response to a ...
Melike Ak +2 more
wiley +1 more source
Extraintestinal Manifestation of Crohn's Disease in the Middle Ear—A Case Report
The Laryngoscope, EarlyView.A unique clinical case with extraintestinal manifestation of Crohn's disease in the middle ear, causing severe inflammation and troublesome symptoms. The combination of systemic therapy and surgery curbed the middle ear manifestation upon diagnosis.
Julia Arebro
wiley +1 more source
Mapping the fitness of Mycobacterium tuberculosis strains: a complex picture.
, 2010 Acquisition of antibiotic resistance in Mycobacterium tuberculosis has been shown to incur a fitness cost; the size of which depends on the position and nature of the mutation. The frequency at which resistant M. tuberculosis strains are isolated in vivo
Gillespie, S. H. +9 more
core +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers +5 more
wiley +1 more source