Results 91 to 100 of about 302,132 (299)

“Mycobacterium indicus pranii” Is a Strain of Mycobacterium intracellulare [PDF]

mBio, 2015
In the recent publication “Comparative Analyses of Nonpathogenic, Opportunistic, and Totally Pathogenic Mycobacteria Reveal Genomic and Biochemical Variabilities and Highlight the Survival Attributes of Mycobacterium tuberculosis,” Rahman et al.
David C. Alexander, Christine Y. Turenne
openaire   +3 more sources

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]

, 2013
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
Nalini Mehta, Joaquín Rullás, Minick, Douglas J, María Martínez-Hoyos, Pallen, Mark J., Rebollo-López María José, Sousa, Verónica, Modesto J. Remuiñán (291058), Chrystala Constantinidou (161352), Johnson Afari, Pérez-Herrán Esther, Jorge Esquivias (403585), Jiménez, Elena, Jiménez Elena, Dow, David J, Constantinidou Chrystala, Fátima Ortega-Muro, Remuiñán, Modesto J, Esquivias Jorge, Fátima Ortega-Muro (403586), Mendoza-Losana, Alfonso, Pallen, Mark J, Lluís Ballell (2196634), Rullás, Joaquín, Besra, Gurdyal S; id_orcid, Vickey L Spivey, María Teresa Fraile-Gabaldón, Carolina González, Sousa Verónica, González, Carolina, Mónica Cacho, Ballell, Lluís, Martínez-Hoyos María, Elena Jiménez (47475), Carolina González (321712), María José Rebollo-López, Pérez-Herrán, Esther, Johnson Afari (403583), Esquivias, Jorge, Spivey, Vickey L., Nicholas J. Loman (126279), Verónica Sousa, Mehta, Nalini, Rebollo-López, María José, Cacho Mónica, Angulo-Barturen, Iñigo, Spivey Vickey L., Barros, David, Vickey L. Spivey (291055), Spivey, Vickey L, Esther Pérez-Herrán, Minick Douglas J., Alfonso Mendoza-Losana (403592), Cacho, Mónica, Nicholas J Loman, Lluís Ballell, Alfonso Mendoza-Losana, Besra, Gurdyal S., Dow David J., Loman, Nicholas J., Mehta Nalini, David J. Dow (403582), Afari, Johnson, Nicholas Cammack (403593), Rullás Joaquín, Iñigo Angulo-Barturen, Esther Pérez-Herrán (403580), Mark J Pallen, Loman, Nicholas J, Carlos Alemparte, Constantinidou, Chrystala, Alemparte Carlos, Fraile-Gabaldón, María Teresa, David J Dow, Douglas J Minick, Remuiñán, Modesto J., Besra Gurdyal S., Gurdyal S. Besra (37660), Remuiñán Modesto J., Chrystala Constantinidou, Mark J. Pallen (8904), Cammack, Nicholas, Ortega-Muro, Fátima, Mendoza-Losana Alfonso, Joaquín Rullás (5654542), Dow, David J., Angulo-Barturen Iñigo, Loman Nicholas J., Nalini Mehta (403584), Alemparte, Carlos, Minick, Douglas J., David Barros (291059), María Teresa Fraile-Gabaldón (403587), Modesto J Remuiñán, Barros David, María Martínez-Hoyos (403581), Mónica Cacho (403589), Cammack Nicholas, Ortega-Muro Fátima, Elena Jiménez, Carlos Alemparte (291057), Afari Johnson, Gurdyal S Besra, Fraile-Gabaldón María Teresa, Martínez-Hoyos, María, David Barros, Iñigo Angulo-Barturen (47469), Ballell Lluís, González Carolina, Douglas J. Minick (403588), Jorge Esquivias, María José Rebollo-López (403590), Pallen Mark J., Nicholas Cammack, Verónica Sousa (403591)   +114 more
core   +1 more source

Immunological characteristics and functions of macrophages in Mycobacterium leprae infection

BMC Immunology
Objective Our research aimed to clarify the roles of M1 and M2 macrophages in leprosy, focusing on their polarization states, phagocytic capacities, and the survival of M. leprae within these macrophage subsets.
Xiaodong Zhang, Haiqin Jiang, Weijun Liu, Hongsheng Wang   +3 more
doaj   +1 more source

A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

eLife, 2019
Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all domains of life, and its homeostasis must be regulated tightly. Here we report that a Nudix-related transcriptional factor, designated MsNrtR (MSMEG_3198), controls the de novo ...
Rongsui Gao, Wenhui Wei, Bachar H Hassan, Jun Li, Jiaoyu Deng, Youjun Feng   +5 more
doaj   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen. [PDF]

, 2002
In order to identify T cell epitopes within the Mycobacterium leprae 45-kD serine-rich antigen, we analysed responses to overlapping 17-mer peptides encompassing the whole antigen in non-exposed UK controls, Pakistani leprosy patients and tuberculosis ...
Zafar, S, Dawood, G, Drijfhout, JW, Smith, S, Lopez, FV, Bothamley, G, Brahmbhatt, S, Hussain, R, Dockrell, HM, Ottenhoff, THM   +9 more
core   +1 more source

Modelling Bovine Granuloma Formation In Vitro upon Infection with Mycobacterium Avium Subspecies Paratuberculosis

Veterinary Sciences, 2019
Mycobacterium avium subspecies paratuberculosis (Map) causes chronic granulomatous disease in cattle and ruminant livestock, causing substantial economic losses.
J. Hunter Rice, Margaret M. McDaniel, Alyson Holland, Shigetoshi Eda   +3 more
doaj   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source