Results 61 to 70 of about 367,380 (311)

The sequential assay of interleukin-10 and 13 serum levels in relation to radiographic changes during pulmonary tuberculosis treatment

Journal of Research in Medical Sciences, 2020
Background: We evaluated the sequential changes of interleukin (IL)-10 and IL-13 serum levels with tuberculosis (TB)-related radiographic changes during pulmonary TB (PTB) treatment.
Sayyed Gholamreza Mortazavi Moghaddam, Mohammad Hasan Namaei, Reza Eslami Manoochehri, Mahmood Zardast   +3 more
doaj   +1 more source

HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.

, 2002
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach.
Lukey, Pauline T, Abdulrahman S. Hammond, McAdam, Keith PWJ, Klein, Michèl R, Jaye, Assan, Smith, Steve M, Michèl R. Klein, Assan Jaye, Steve M. Smith, Hammond, Abdulrahman S, Pauline T. Lukey, Keith P. W. J. McAdam   +11 more
core   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Assessing the accuracy of the updated Fujifilm SILVAMP TB LAM II assay between lot numbers

IJTLD Open
BACKGROUND: The Fujifilm SILVAMP TB LAM (FujiLAM) assay, a point-of-care test detecting urine-based lipoarabinomannans, has demonstrated notable diagnostic accuracy for TB. However, FujiLAM exhibits lot-to-lot variability, limiting its clinical use.
K. Chikamatsu, Y. Shimomura, A. Osugi, S. Mitarai   +3 more
doaj   +1 more source

Intravitreal piperacillin-tazobactam in endophthalmitis caused by Mycobacterium abscessus in silico ne-filled eye: A case report

Indian Journal of Ophthalmology, 2020
A 28-year-old female came to us one month after retinal detachment surgery with a sudden painless drop in vision. The condition gradually worsened with ongoing treatment so she was taken up for lensectomy with silicone oil removal and intravitreal ...
G Suganeswari, Dhaivat Shah, Appakkudal R Anand   +2 more
doaj   +1 more source

Something Old, Something New: Ion Channel Blockers as Potential Anti-Tuberculosis Agents

Frontiers in Immunology, 2021
Tuberculosis (TB) remains a challenging global health concern and claims more than a million lives every year. We lack an effective vaccine and understanding of what constitutes protective immunity against TB to inform rational vaccine design.
Steven C. Mitini-Nkhoma, Elizabeth T. Chimbayo, David T. Mzinza, David T. Mzinza, David V. Mhango, David V. Mhango, Aaron P. Chirambo, Christine Mandalasi, Agness E. Lakudzala, Dumizulu L. Tembo, Kondwani C. Jambo, Kondwani C. Jambo, Henry C. Mwandumba, Henry C. Mwandumba   +13 more
doaj   +1 more source

MabsBase: A Mycobacterium abscessus Genome and Annotation Database [PDF]

, 2013
Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterial species that has been associated with a wide spectrum of human infections. As the classification and biology of this organism is still not well understood, comparative genomic ...
Lokanathan, N., Wong, G. J., Guat Jah Wong, Ranjeev Hari, Wei Yee Wee, Yun Fong Ngeow, Wee, W. Y., Yusoff, A. M., Beh, C. Y., Ching Yew Beh, Heydari, H., Choo, S. W., Yew Beh, Aini Mohamed Yusoff, Hari, R., Ngeow, Y. F., Hamed Heydari, Siew Woh Choo, Naline Lokanathan, Yazdi, A. H., Amir Hessam Yazdi   +20 more
core   +2 more sources

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Expression of dnaE2 promotes genetic diversity in mycobacterial biofilms

Frontiers in Cellular and Infection Microbiology
The complex cellular architecture and microenvironments within biofilms give rise to a physiologically and genetically heterogeneous population. Transcriptome analysis of Mycobacterium smegmatis from biofilm culture and its transition phase into ...
S. Salini, Sinchana G. Bhat, M. Nijisha, Kumar Paritosh, Reshma Ramachandran, Nikhil Nikolas, Saba Naz, Krishna Kurthkoti   +7 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source