Results 41 to 50 of about 1,040,351 (259)
International Journal of Infectious Diseases, 2019 Ruxolitinib is a JAK-1/JAK-2 inhibitor indicated for the treatment of polycythemia vera and primary or secondary myelofibrosis. Only one patient (0.2%) was diagnosed with tuberculosis among the 485 patients receiving ruxolitinib in the four pivotal ...
Sylvain Lescuyer +9 more
doaj +1 more source
Skin and soft tissue infection by Mycobacterium intracellulare in an immunocompetent patient
IDCases, 2020 Nontuberculous mycobacteria (NTM) infections still represent a large group of insidious diseases hard to deal with. Traditionally, immunocompromised patients suffer from NTM infections, especially with respiratory involvement or disseminated diseases due
Alessio Pampaloni +9 more
doaj +1 more source
Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity
Advanced Science, EarlyView.Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten +30 more
wiley +1 more source
Angewandte Chemie, EarlyView.An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee +7 more
wiley +2 more sources
A Rare Case of Intestinal Tuberculosis Mimicking Colon Cancer in a Chronic Kidney Disease Patient
Journal of Clinical and Diagnostic ResearchIntestinal Tuberculosis (ITB) is an uncommon form of extrapulmonary TB that poses a diagnostic challenge due to its nonspecific symptoms and radiological resemblance to malignancy.
Anuja Makan +4 more
doaj +1 more source
Advanced Science, EarlyView.In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin +8 more
wiley +1 more source
Respirology Case ReportsTuberculosis and leprosy coinfection is increasingly rare even in endemic areas. We report a 70‐year‐old male presenting with fever and malaise. Pulmonary tuberculosis was suggested by chest computed tomography scan and confirmed on polymerase chain ...
Cary Amiel G. Villanueva +3 more
doaj +1 more source
Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase TpX. [PDF]
, 2009 The macrophage is the natural niche of Mycobacterium tuberculosis infection. In order to combat oxidative and nitrosative stresses and persist in macrophages successfully, M. tuberculosis is endowed with a very efficient antioxidant complex.
Hu, Y +4 more
core +2 more sources
Advanced Science, EarlyView.This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source
Salud Pública de México, 1998 Objetivo. Determinar la prevalencia de infección tuberculosa en escolares de la ciudad de Tijuana, México. Material y métodos. Se seleccionó aleatoriamente una muestra a partir del registro escolar municipal y se incluyeron 1 131 estudiantes de primaria ...
RAFAEL LANIADO-LABORÍN +5 more
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