Results 51 to 60 of about 139,802 (315)

Bone and joint infections due to opportunistic mycobacteria, a review of French experience

International Journal of Mycobacteriology, 2015
Aims and objectives: Bone and joint infections due to environmental mycobacteria are rare and can develop very slowly. The source for these outbreaks is generally tap water supplies.
Véronique Vincent
doaj   +1 more source

Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies

Respirology Case Reports, 2023
Anti‐interferon‐gamma autoantibody (AIGA) is a rare adult‐onset immunodeficiency disease that increases the risk of occult infection. Nontuberculous mycobacteria (NTM) infections represent a diverse group of species and subspecies, and mixed infections ...
Yun‐Tse Chou, Wei‐An Liao, Chin‐Wei Kuo   +2 more
doaj   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Mycobacterium massiliense BRA100 strain recovered from postsurgical infections: resistance to high concentrations of glutaraldehyde and alternative solutions for high level disinfection Mycobacterium massiliense clone BRA100 associado a infecções pós-cirúrgicas: resistência a altas concentrações de glutaraldeído e produtos alternativos para desinfecção de alto nível

Acta Cirúrgica Brasileira, 2010
PURPOSE: To evaluate the minimum inhibitory concentration (MIC) of GTA against these microorganisms and alternative disinfectants for high-level disinfection (HLD). METHODS: Reference mycobacteria and clinical M. massiliense strains were included in this
Nádia Suely de Oliveira Lorena, Marcos Bettini Pitombo, Patrícia Barbur Côrtes, Maria Cristina Araújo Maya, Marlei Gomes da Silva, Ana Carolina da Silva Carvalho, Fábrice Santana Coelho, Neide Hiromi Tokumaru Miyazaki, Elizabeth Andrade Marques, Alberto Chebabo, Andréa D'Ávila Freitas, Otília Lupi, Rafael Silva Duarte   +12 more
doaj   +1 more source

Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis

Animal Models and Experimental Medicine, EarlyView.
This study developed a biosafe, accessible, and versatile murine model of bone TB using Mycobacterium smegmatis, a fast‐growing, nonpathogenic mycobacterial species with high genomic homology to Mycobacterium tuberculosis. Three infection routes—subperiosteal calvarial injection, intratibial injection, and intracardiac (left ventricular) inoculation ...
Yewei Jia, Yuhuai Guo, Yusheng Yang, Jie Zhang, Ziyang Zhang, Ying Qu, Jiulin Tan, Jie Shen, Nathachit Limjunyawong, Jianzhong Xu, Zehua Zhang, Fei Luo, Ce Dou   +12 more
wiley   +1 more source

Beyond the Needle: Unmasking Atypical Mycobacteria in Postvaccination Abscesses in Children

Journal of Indian Association of Pediatric Surgeons
Introduction: Atypical or nontuberculous mycobacteria (NTM) are an environmental organism responsible for opportunistic infection. Rapid-growing NTM are more commonly associated with hospital-acquired infections.
Amar Shah, Devesh N. Joshi, Anirudh Shah
doaj   +1 more source

A case of hepatitis B and mycobacterium leprae co-infection causing challenges in diagnosis and treatment [PDF]

, 2021
Abate Bane
openalex   +1 more source

Buruli ulcer: Mycobacterium ulcerans infection

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008
Abstract Buruli ulcer is caused by Mycobacterium ulcerans, which secretes a cytotoxic and immunosuppressive toxin, mycolactone. The disease is characterized by necrosis of skin, subcutaneous tissue, and bone, and is re-emerging as a potentially disabling affliction of inhabitants of tropical wetlands.
Walsh, D. S., Portaels, F., Meyers, W. M.   +2 more
openaire   +4 more sources