Results 11 to 20 of about 174,365 (247)

Subversion of Schwann Cell Glucose Metabolism by Mycobacterium leprae* [PDF]

Journal of Biological Chemistry, 2016
Mycobacterium leprae, the intracellular etiological agent of leprosy, infects Schwann promoting irreversible physical disabilities and deformities. These cells are responsible for myelination and maintenance of axonal energy metabolism through export of ...
R. C. Medeiros, K. Girardi, Fernanda Karlla Luz Cardoso, B. S. Mietto, Thiago Gomes de Toledo Pinto, Lilian S. Gomez, L. Rodrigues, M. Gandini, J. J. Amaral, S. G. Antunes, S. Côrte‐Real, P. Rosa, M. C. Pessolani, J. Nery, E. Sarno, L. R. Batista-Silva, M. Sola-Penna, Marcus F. Oliveira, M. Moraes, F. Lara   +19 more
semanticscholar   +2 more sources

Reverse vaccinology and subtractive genomics approaches for identifying common therapeutics against Mycobacterium leprae and Mycobacterium lepromatosis [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Mycobacterium leprae and Mycobacterium lepromatosis are gram-positive bacterial pathogens and the causative agents of leprosy in humans across the world.
Arun Kumar Jaiswal, Sandeep Tiwari, Syed Babar Jamal, Letícia de Castro Oliveira, Helioswilton Sales-Campos, Leonardo Eurípedes Andrade-Silva, Carlo Jose Freire Oliveira, Preetam Ghosh, Debmalya Barh, Vasco Azevedo, Siomar C. Soares, Virmondes Rodrigues Junior, Marcos Vinicius da Silva   +12 more
doaj   +1 more source

Takayasu Arteritis in a 55-Year-Old Woman With Prior <i>Mycobacterium leprae</i> Infection: A Possible Postinfectious Association. [PDF]

Clin Case Rep
ABSTRACT Takayasu arteritis (TAK) is a rare large‐vessel vasculitis affecting the aorta and its major branches. Although autoimmune mechanisms are central, prior mycobacterial infections have been hypothesized to contribute to the disease onset. A 55‐year‐old South Asian woman with a history of vitiligo and treated multibacillary leprosy presented with
Bhattarai U, Jha A, Shrestha I, Lamar N, Parajuli M, Bhujel S, Majhi D, Paudel K.   +7 more
europepmc   +2 more sources

In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae

Immunological Reviews, 2021
Mycobacterium leprae, the causative agent of leprosy, is still actively transmitted in endemic areas reflected by the fairly stable number of new cases detected each year.
Anouk van Hooij, A. Geluk
semanticscholar   +1 more source

Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes

BMC Biology, 2021
Hansen’s disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually.
S. Pfrengle, Judith Neukamm, Meriam Guellil, Marcel Keller, Martyna Molak, C. Avanzi, A. Kushniarevich, N. Montes, Gunnar U. Neumann, Ella Reiter, R. Tukhbatova, N. Berezina, A. Buzhilova, D. Korobov, Stian Suppersberger Hamre, Vítor M. J. Matos, M. T. Ferreira, L. González-Garrido, S. Wasterlain, Célia Lopes, A. L. Santos, Nathalie Antunes‐Ferreira, Vitoria Duarte, A. Silva, Linda Melo, Nataša Šarkić, Lehti Saag, K. Tambets, P. Busso, S. Cole, A. Avlasovich, C. Roberts, A. Sheridan, C. Cessford, J. Robb, J. Krause, C. Scheib, S. Inskip, V. Schuenemann   +38 more
semanticscholar   +1 more source

Reduction of host cell mitochondrial activity as Mycobacterium leprae’s strategy to evade host innate immunity

Immunological Reviews, 2021
Leprosy is a much‐feared incapacitating infectious disease caused by Mycobacterium leprae or M lepromatosis, annually affecting roughly 200,000 people worldwide.
Marcus F. Oliveira, R. C. Medeiros, B. S. Mietto, Thyago Leal-Calvo, A. P. M. Mendonça, T. L. S. A. Rosa, D. Silva, Karina Girardi do Carmo de Vasconcelos, Antônio Marcos Rodrigues Pereira, C. S. de Macedo, G. M. Pereira, Marcia de Berrêdo Pinho Moreira, M. C. Pessolani, M. Moraes, Flavio Alves Lara   +14 more
semanticscholar   +1 more source

The genetic determinants of Mycobacterium leprae resistance to antimicrobial drugs [PDF]

Vestnik Dermatologii i Venerologii, 2021
The review is devoted to the appearance of resistance of a slowly developing disease leprosy to antimicrobial therapy (AMP), primarily recommended by the World Health Organization.
Dmitry A. Verbenko, Victoria S. Solomka, Irina V. Kozlova, Alexey A. Kubanov   +3 more
doaj   +1 more source

Construction and Analysis of the Complete Genome Sequence of Leprosy Agent Mycobacterium lepromatosis

Microbiology Spectrum, 2022
Leprosy is caused by Mycobacterium leprae and Mycobacterium lepromatosis. We report construction and analyses of the complete genome sequence of M. lepromatosis FJ924.
Francisco J. Silva, Diego Santos-Garcia, Xiaofeng Zheng, Li Zhang, Xiang Y. Han   +4 more
doaj   +1 more source

Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae [PDF]

Frontiers in Microbiology, 2021
In 1926, a mycobacterial skin disease was observed in water buffaloes by researchers in Indonesia. The disease was designated as skin tuberculosis, though it was hypothesized that it might be a form of leprosy or a leprosy-like disease. In a follow-up study (Ph.D.
William R. Faber, Henk Menke, Victor Rutten, Victor Rutten, Toine Pieters   +4 more
openaire   +5 more sources

Mycobacterium leprae on Palatine Tonsils and Adenoids of Asymptomatic Patients, Brazil

Emerging Infectious Diseases, 2020
We investigated palatine tonsil and adenoid specimens excised from otorhinolaryngological patients in a leprosy-endemic region of Brazil. Fite-Faraco staining identified Mycobacterium spp. in 9 of 397 specimen blocks.
Marilda Aparecida Milanez Morgado de Abreu, Gisele Alborghetti Nai, Juliana D’Andrea Molina, Rafael Tomaz Gomes, Ana Maria Roselino Natalia de Paula   +4 more
doaj   +1 more source