Results 51 to 60 of about 174,365 (247)

Oral Treatment With Heat Shock Protein 65‐Producing Lactococcus lactis Induces Regulatory T Cells, Modulating Inflammatory Response in Leishmania braziliensis Infection

Immunology, Volume 177, Issue 1, Page 59-69, January 2026.
Oral treatment with HSP65‐producing Lactococcus lactis after Leishmania braziliensis infection modulates inflammation by promoting lesion resolution through increased IL‐10 production and expansion of regulatory T cells. These findings highlight the potential of oral tolerance induction as a promising therapeutic strategy for chronic inflammatory ...
Camila Mattos Andrade, Ítalo da Silva Gonçalves, Maria Luiza das Neves Nascimento, Washington Luís Conrado Santos, Vasco Ariston Azevedo, Deborah Bittencourt Mothé, Juliana Perrone Menezes Fullam, Patrícia Sampaio Tavares Veras, Natalia Machado Tavares, Tatiani Uceli Maioli, Ana Maria Caetano Faria, Cláudia Ida Brodskyn   +11 more
wiley   +1 more source

Importance of the immune response to Mycobacterium leprae in the skin

Biomedical Dermatology, 2018
The causative agent of leprosy is Mycobacterium leprae (M. leprae), which establishes infectious lesions in the skin. Leprosy is classified based on the clinical manifestation, the host’s immune response and skin symptoms. M.
Song-Hyo Jin, K. Ahn, S. An
semanticscholar   +1 more source

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

A Zebrafish Model of Mycobacterium leprae Granulomatous Infection

bioRxiv, 2017
Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at ~30°C, so we sought to model granulomatous disease in the ...
Cressida A. Madigan, James Cameron, L. Ramakrishnan   +2 more
semanticscholar   +1 more source

Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017

Emerging Infectious Diseases, 2020
Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to ...
Qingtian Guan, Talal S. Almutairi, Tahani Alhalouli, Arnab Pain, Faisal Alasmari   +4 more
doaj   +1 more source

Faktor-Faktor yang Mempengaruhi Terjadinya Infeksi Kusta

JKS (Jurnal Kedokteran Syiah Kuala), 2010
Abstrak.  Program pemberantasan kusta di dunia telah berjalan Jebih dari 20 tahun terakhir, namun kasus insiden kusta baru tidak menurun. Dengan kata lain penularan penyakit kusta masih terus terjadi di rnana- mana.
Mudatsir Mudatsir
doaj  

Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis.

PLoS Neglected Tropical Diseases, 2022
Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae, an obligate intracellular bacterium. Timely detection is a challenge in leprosy diagnosis, relying on clinical examination and trained health professionals.
Fernanda Saloum de Neves Manta, Thiago Jacomasso, Rita de Cássia Pontello Rampazzo, Suelen Justo Maria Moreira, Najua M Zahra, Stewart T Cole, Charlotte Avanzi, Thyago Leal-Calvo, Sidra Ezidio Gonçalves Vasconcellos, Phillip Suffys, Marcelo Ribeiro-Alves, Marco Aurelio Krieger, Alexandre Dias Tavares Costa, Milton Ozório Moraes   +13 more
doaj   +1 more source

Uncovering Insights Into the Biology of Mycobacterium tuberculosis Using Genetic Tools

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Genetic manipulation tools such as homologous recombination, CRISPR‐Cas systems, and gene knock‐out/knock‐down strategies have advanced Mycobacterium tuberculosis (Mtb) research, despite challenges posed by its slow growth, complex pathology, and drug resistance.
Alessandro Stamilla, Deborah Recchia, Giovanni Stelitano, Ludovica Maci, Maria Concetta Marturano, Edda De Rossi, Laurent Roberto Chiarelli, Maria Rosalia Pasca, Giulia Degiacomi   +8 more
wiley   +1 more source

Natural environmental water sources in endemic regions of northeastern Brazil are potential reservoirs of viable Mycobacterium leprae

Memórias do Instituto Oswaldo Cruz, 2017
BACKGROUND The detection of live Mycobacterium leprae in soil and animals other than humans suggests that the environment plays a role in the transmission of leprosy.
Maria Luisa Bezerra de Macedo Arraes, Maísa Viana de Holanda, L. N. Lima, J. A. B. Sabadia, C. R. Duarte, R. Almeida, C. Kendall, L. Kerr, C. Frota   +8 more
semanticscholar   +1 more source

From leprosy to ground zero: Imagining futures in a world of elimination

Medical Anthropology Quarterly, Volume 39, Issue 4, December 2025.
Abstract Achieving a target of zero—zero disease, zero disability, and zero discrimination—has become the dominant focus of campaigns to control or eliminate diseases, from HIV/AIDS to malaria to leprosy. Given the historical failure of most eradication programs over the last century, such teleological imaginings of disease‐free futures might seem ...
James Staples
wiley   +1 more source