Results 51 to 60 of about 30,636 (254)

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

Frontiers in Microbiology, 2022
The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to leprosy in a small subset of the infected individuals. Transmission is believed to occur mainly by exposure to bacilli present in aerosols expelled by infected ...
Natasha Cabral, Vilma de Figueiredo, Mariana Gandini, Cíntia Fernandes de Souza, Rychelle Affonso Medeiros, Letícia Miranda Santos Lery, Flávio Alves Lara, Cristiana Santos de Macedo, Maria Cristina Vidal Pessolani, Geraldo Moura Batista Pereira   +9 more
doaj   +1 more source

Coexistence of Scrofuloderma and Lepromatous Leprosy in Reaction: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Leprosy and tuberculosis (TB) are both chronic granulomatous infections caused by bacilli of the genus Mycobacterium. The simultaneous occurrence of cutaneous tuberculosis and leprosy is rare. We report a 56‐year‐old male presenting with painful erythematous nodules and plaques over the face and extremities for 1 week, along with asymptomatic ...
Anupa Khadka, Punam Mishra, Akanshya Shrestha, Gunawati Chaulagain   +3 more
wiley   +1 more source

Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017

Emerging Infectious Diseases, 2020
Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to ...
Qingtian Guan, Talal S. Almutairi, Tahani Alhalouli, Arnab Pain, Faisal Alasmari   +4 more
doaj   +1 more source

Diagnostic assays for leprosy based on T-cell epitopes. [PDF]

, 2000
To date, only a limited number of antigens have been described as specific for Mycobacterium leprae, and in many cases, homologues have subsequently been shown to exist in mycobacteria such as M. avium and M. intracellulare.
Brahmbhatt, S, Britton, S, Dockrell, H M, Fruth, U, Gebre, N, Hunegnaw, M, Hussain, R, Manadhar, R, Murrillo, L, Pessolani, M C, Robertson, B D, Roche, P, Salgado, J L, Sampaio, E, Shahid, F, Thole, J E, Young, D B   +16 more
core   +1 more source

Oral Treatment With Heat Shock Protein 65‐Producing Lactococcus lactis Induces Regulatory T Cells, Modulating Inflammatory Response in Leishmania braziliensis Infection

Immunology, Volume 177, Issue 1, Page 59-69, January 2026.
Oral treatment with HSP65‐producing Lactococcus lactis after Leishmania braziliensis infection modulates inflammation by promoting lesion resolution through increased IL‐10 production and expansion of regulatory T cells. These findings highlight the potential of oral tolerance induction as a promising therapeutic strategy for chronic inflammatory ...
Camila Mattos Andrade, Ítalo da Silva Gonçalves, Maria Luiza das Neves Nascimento, Washington Luís Conrado Santos, Vasco Ariston Azevedo, Deborah Bittencourt Mothé, Juliana Perrone Menezes Fullam, Patrícia Sampaio Tavares Veras, Natalia Machado Tavares, Tatiani Uceli Maioli, Ana Maria Caetano Faria, Cláudia Ida Brodskyn   +11 more
wiley   +1 more source

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Lipid Body–Phagosome Interaction in Macrophages during Infectious Diseases: Host Defense or Pathogen Survival Strategy? [PDF]

, 2012
Phagocytosis of invading microorganisms by specialized cells such as macrophages and neutrophils is a key component of the innate immune response. These cells capture and engulf pathogens and subsequently destroy them in intracellular vacuoles—the ...
Dvorak, Ann Marie, Melo, Rossana C. N.
core   +2 more sources

Faktor-Faktor yang Mempengaruhi Terjadinya Infeksi Kusta

JKS (Jurnal Kedokteran Syiah Kuala), 2010
Abstrak.  Program pemberantasan kusta di dunia telah berjalan Jebih dari 20 tahun terakhir, namun kasus insiden kusta baru tidak menurun. Dengan kata lain penularan penyakit kusta masih terus terjadi di rnana- mana.
Mudatsir Mudatsir
doaj  

Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis.

PLoS Neglected Tropical Diseases, 2022
Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae, an obligate intracellular bacterium. Timely detection is a challenge in leprosy diagnosis, relying on clinical examination and trained health professionals.
Fernanda Saloum de Neves Manta, Thiago Jacomasso, Rita de Cássia Pontello Rampazzo, Suelen Justo Maria Moreira, Najua M Zahra, Stewart T Cole, Charlotte Avanzi, Thyago Leal-Calvo, Sidra Ezidio Gonçalves Vasconcellos, Phillip Suffys, Marcelo Ribeiro-Alves, Marco Aurelio Krieger, Alexandre Dias Tavares Costa, Milton Ozório Moraes   +13 more
doaj   +1 more source

Length, Protein-Protein Interactions, and Complexity

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear.
Albert, Bateman, Bates, Bates, Boeckmann, Carlson, Daan Frenkel, Eisenhaber, Hasty, Hopkins, Jeong, Jeong, Lander, Mewes, Michael W. Deem, Mott, Prost, Rhines, Riddle, Steinmetz, Strausberg, Taison Tan, Uetz, Vishal Gupta, Watts, Waxman, Zhang, Zhang   +27 more
core   +1 more source