Results 111 to 120 of about 843,867 (389)

In Situ Vaccines in the Era of Cancer Immunotherapy: Conceptual Innovation and Clinical Translation

Advanced Science, EarlyView.
In this review, the basic concepts of in situ vaccination are discussed, its advantages over conventional vaccines, and key historical milestones, from the first use of Coley's toxins to the most recent FDA‐approved in situ vaccine for bladder cancer.
Yiru Shi, Yuxuan Hou, Moustafa T. Mabrouk, Chengzhong Yu, Yannan Yang   +4 more
wiley   +1 more source

Type I interferons in tuberculosis: Foe and occasionally friend [PDF]

, 2018
Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K, Moreira-Teixeira, L, O'Garra, A, Sher, A   +3 more
core   +1 more source

Diosgenin ameliorates silica‐induced tuberculosis in rats

Animal Models and Experimental Medicine, EarlyView.
Silicosis increases susceptibility to tuberculosis due to impaired macrophage function and oxidative stress. This study demonstrates that diosgenin, a steroidal saponin, significantly inhibits Mycobacterium smegmatis (IC₅₀ = 0.006 μg/mL), reduces lung fibrosis, and restores antioxidant enzyme levels (↑SOD, ↑CAT, ↓MDA) in silica‐exposed rats ...
Williams Asamoah Adu, Selase Ativui, Michael Ofori, George Owusu, Cynthia Amaning Danquah, Paul Poku Sampene Ossei   +5 more
wiley   +1 more source

Mycobacterium tuberculosis Lineage 4 comprises globally distributed and geographically restricted sublineages

Nature Genetics, 2016
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens.
David Stucki, D. Brites, Leïla Jeljeli, M. Coscollá, Qingyun Liu, Andrej Trauner, L. Fenner, Liliana K. Rutaihwa, S. Borrell, Tao Luo, Q. Gao, M. Kato-Maeda, M. Ballif, M. Egger, R. Macedo, H. Mardassi, Milagros Moreno, Griselda Tudo Vilanova, J. Fyfe, M. Globan, Jackson Thomas, F. Jamieson, J. Guthrie, Adwoa Asante-Poku, D. Yeboah-Manu, E. Wampande, W. Ssengooba, M. Joloba, W. Henry Boom, I. Basu, J. Bower, M. Saraiva, S. E. G. Vaconcellos, P. Suffys, A. Koch, R. Wilkinson, L. Gail-Bekker, Bijaya Malla, Serej D. Ley, H. Beck, B. D. de Jong, K. Toit, E. Sánchez-Padilla, M. Bonnet, A. Gil-Brusola, M. Frank, V. P. Penlap Beng, K. Eisenach, Issam Alani, Perpetual Wangui Ndung’u, G. Revathi, F. Gehre, Suriya Akter, F. Ntoumi, Lynsey Stewart-Isherwood, N. Ntinginya, A. Rachow, M. Hoelscher, D. Cirillo, G. Skenders, S. Hoffner, D. Bakonytė, P. Stakėnas, R. Diel, V. Crudu, O. Moldovan, S. Al-Hajoj, L. Otero, F. Barletta, E. Jane Carter, L. Diero, P. Supply, I. Comas, S. Niemann, S. Gagneux   +74 more
semanticscholar   +1 more source

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, EarlyView.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain [PDF]

, 2015
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a
Balloux, Francois, Eldholm, Vegard, Lopez, Beatriz, Monteserin, Johana, Rieux, Adrien, Ritacco, Gloria Viviana, Sobkowiak, Benjamin   +6 more
core   +4 more sources

Noncoding RNAs in Host–Microbiota Interaction

Animal Research and One Health, EarlyView.
The intricate interplay between gut microbiota and the host exerts a profound impact on host biological processes and disease development. This review highlights the pivotal role of noncoding RNAs (ncRNAs) in this interaction. Host ncRNAs regulate gene expression and microbiota composition, whereas microbial small RNAs (sRNAs) modulate host gene ...
Ziyi Zhao, Ni Li, Jingyi Xu, Jianrong Ren, Xiaojun Yang, Xinyi Li, Junhu Yao, Shengru Wu   +7 more
wiley   +1 more source

Phospholipase C in Beijing strains of Mycobacterium tuberculosis

Iranian Journal of Microbiology, 2010
Background and Objectives: Phospholipase of Mycobacterium tuberculosis plays an important role in pathogenesis through breaking up phospholipids and production of diacylglycerol.
H Goudarzi, ES Mirsamadi, S Jahani Sherafat, M Esfahani, N Faramarzi, P Farnia   +5 more
doaj  

Drug Resistance in Mycobacterium tuberculosis

Mycobacterium - Research and Development, 2017
Tuberculosis (TB) remains to be a serious health problem worldwide. There is an increased transmission of Mycobacterium tuberculosis strains with drug resistance, hence complicat‐ ing TB control. The deciphering of the M.
K. Peñuelas-Urquides, Fabiola Castorena-Torres, B. Silva-Ramírez, Mario Bermúdez de León   +3 more
semanticscholar   +1 more source

Gout and NLRP3 Inflammasome Biology

Arthritis &Rheumatology, EarlyView.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source