Journal of Clinical Microbiology, 1993 DNA fingerprinting of Mycobacterium tuberculosis has been shown to be a powerful epidemiologic tool. We propose a standardized technique which exploits variability in both the number and genomic position of IS6110 to generate strain-specific patterns ...
A. JAND. +12 more
semanticscholar +1 more source
Miniaturised Spotter-Compatible Multicapillary Stamping Tool for Microarray Printing [PDF]
Biotechniques. 2007 May; 42(5):590, 592, 594, 2007 Novel microstamping tool for microarray printing is proposed. The tool is capable to spot up to 127 droplets of different solutions in single touch. It is easily compatible with commercially available microarray spotters. The tool is based on multichannel funnel with polypropylene capillaries inserted into its channels. Superior flexibility is achieved
arxiv
Gamma Interferon Release Assays for Detection of Mycobacterium tuberculosis Infection
Clinical Microbiology Reviews, 2014 SUMMARY Identification and treatment of latent tuberculosis infection (LTBI) can substantially reduce the risk of developing active disease. However, there is no diagnostic gold standard for LTBI.
M. Pai +10 more
semanticscholar +1 more source
'Perfectly' curvilinear profiles for binding as determined by ITC may in fact be multiphasic [PDF]
arXiv, 2016 In a structural analysis of the proteasome activator PafE in Mycobacterium tuberculosis, the binding of the activator or shorter constructs to the 20S proteasome core particle (20S CP) or derivatives was measured by isothermal titration calorimetry (Bai et al. Proc Natl Acad Sci USA 113: E1983-E1992. 2016).
arxiv
On the ability to reconstruct ancestral genomes from Mycobacterium genus [PDF]
arXiv, 2017 Technical signs of progress during the last decades has led to a situation in which the accumulation of genome sequence data is increasingly fast and cheap. The huge amount of molecular data available nowadays can help addressing new and essential questions in Evolution.
arxiv
Modelling the Structure of a Protein Domain (N-terminal of XPB) Linked with Protein Synthesis, DNA Damage Repair, Rare Diseases, Cancer Therapeutics, and Tuberculosis [PDF]
arXiv, 2016 In this work, we develop first near-complete 3D models for NTD-hXPB - the N-terminal protein domain of the human transcription factor XPB. The results are very significant as NTD-hXPB plays a critical role in the synthesis of proteins (specifically transcription) and DNA damage repair (specifically nucleotide excision repair).
arxiv
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Nature, 1998 S. Cole +41 more
semanticscholar +1 more source
Enhanced Tuberculosis Bacilli Detection using Attention-Residual U-Net and Ensemble Classification [PDF]
arXivTuberculosis (TB), caused by Mycobacterium tuberculosis, remains a critical global health issue, necessitating timely diagnosis and treatment. Current methods for detecting tuberculosis bacilli from bright field microscopic sputum smear images suffer from low automation, inadequate segmentation performance, and limited classification accuracy.
arxiv
A reaction-diffusion model for Mycobacterium tuberculosis infection [PDF]
arXivThis paper aims to investigate a reaction-diffusion model which describes in-host infection for Mycobacterium tuberculosis (Mtb) allowing random motion (i.e. linear diffusion) and chemotaxis (i.e. non-linear diffusion) of macrophages and bacteria populations.
arxiv
Few-Shot Learning Approach on Tuberculosis Classification Based on Chest X-Ray Images [PDF]
arXivTuberculosis (TB) is caused by the bacterium Mycobacterium tuberculosis, primarily affecting the lungs. Early detection is crucial for improving treatment effectiveness and reducing transmission risk. Artificial intelligence (AI), particularly through image classification of chest X-rays, can assist in TB detection. However, class imbalance in TB chest
arxiv