Results 21 to 30 of about 123,926 (204)

Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer. [PDF]

PLoS Neglected Tropical Diseases, 2009
Mycolactone A/B is a lipophilic macrocyclic polyketide that is the primary virulence factor produced by Mycobacterium ulcerans, a human pathogen and the causative agent of Buruli ulcer. In M. ulcerans strain Agy99 the mycolactone polyketide synthase (PKS)
Nicholas J Tobias, Torsten Seemann, Sacha J Pidot, Jessica L Porter, Laurent Marsollier, Estelle Marion, Franck Letournel, Tasnim Zakir, Joseph Azuolas, John R Wallace, Hui Hong, John K Davies, Benjamin P Howden, Paul D R Johnson, Grant A Jenkin, Timothy P Stinear   +15 more
doaj   +1 more source

Screening anti-infectious molecules against Mycobacterium ulcerans: A step towards decontaminating environmental specimens.

PLoS ONE, 2020
Mycobacterium ulcerans, a non-tuberculous mycobacterium responsible for Buruli ulcer, resides in poorly defined environmental niches in the vicinity of stagnant water. Very few isolates have been confirmed. With a view to culturing M.
Nassim Hammoudi, Romain Verdot, Jean Delorme, Amar Bouam, Michel Drancourt   +4 more
doaj   +1 more source

Mycobacterium ulcerans fails to infect through skin abrasions in a guinea pig infection model: implications for transmission. [PDF]

PLoS Neglected Tropical Diseases, 2014
Transmission of M. ulcerans, the etiological agent of Buruli ulcer, from the environment to humans remains an enigma despite decades of research. Major transmission hypotheses propose 1) that M.
Heather R Williamson, Lydia Mosi, Robert Donnell, Maha Aqqad, Richard W Merritt, Pamela L C Small   +5 more
doaj   +1 more source

Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease. [PDF]

, 2015
Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries.
Kerber, Sarah, Zimmer, Gert, Miriam Bolz, Sarah Kerber (421868), Bolz, Miriam, Gerd Pluschke, Miriam Bolz (309717), Gert Zimmer, Sarah Kerber, Gerd Pluschke (7855), Pluschke, Gerd, Gert Zimmer (223023), Kerber S, Bolz Miriam, Pluschke G, Zimmer G, Kerber Sarah, Pluschke Gerd, Bolz M, Zimmer Gert   +19 more
core   +3 more sources

Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: The World Health Organization currently recommends combined streptomycin and rifampicin antibiotic treatment as first-line therapy for Mycobacterium ulcerans infections.
Daniel P O'Brien, Anthony McDonald, Peter Callan, Mike Robson, N Deborah Friedman, Andrew Hughes, Ian Holten, Aaron Walton, Eugene Athan   +8 more
doaj   +1 more source

A sero-epidemiological approach to explore transmission of Mycobacterium ulcerans [PDF]

, 2016
The debilitating skin disease Buruli ulcer (BU) is caused by infection with Mycobacterium ulcerans. While various hypotheses on potential reservoirs and vectors of M. ulcerans exist, the mode of transmission has remained unclear.
Yeboah-Manu, Dorothy, Amanda Ross, Gerd Pluschke, Amanda Ross (187821), Daniel De-Graft (848163), Ross, Amanda, Sarah Kerber, Katharina Röltgen, Dorothy Yeboah-Manu (120059), Mahavir Singh, Prince Asare (848162), Singh, Mahavir, Beatrice Nickel (848161), Sarah Kerber (421868), Ralf Spallek, Mahavir Singh (70735), Daniel De-Graft, Kobina Assan Ampah, Kerber, Sarah, Spallek, Ralf, Ralf Spallek (70732), Röltgen, Katharina, Beatrice Nickel, Gerd Pluschke (7855), Katharina Röltgen (120045), De-Graft, Daniel, Kobina Assan Ampah (848160), Ampah, Kobina Assan, Nickel, Beatrice, Dorothy Yeboah-Manu, Asare, Prince, Prince Asare, Pluschke, Gerd, Spallek R, Nickel B, Singh Mahavir, Kerber Sarah, Spallek Ralf, Ampah KA, Singh M, Kerber S, Pluschke G, Nickel Beatrice, Ampah Kobina Assan, Yeboah-Manu D, Röltgen K, Asare Prince, Röltgen Katharina, Asare P, Ross A, Pluschke Gerd, Ross Amanda, De-Graft Daniel, Yeboah-Manu Dorothy, De-Graft D   +54 more
core   +2 more sources

In-vitro activity of avermectins against Mycobacterium ulcerans. [PDF]

PLoS Neglected Tropical Diseases, 2015
Mycobacterium ulcerans causes Buruli ulcer (BU), a debilitating infection of subcutaneous tissue. There is a WHO-recommended antibiotic treatment requiring an 8-week course of streptomycin and rifampicin.
Till F Omansen, Jessica L Porter, Paul D R Johnson, Tjip S van der Werf, Ymkje Stienstra, Timothy P Stinear   +5 more
doaj   +1 more source

Buruli ulcer: The Efficacy of Innate Immune Defense May Be a Key Determinant for the Outcome of Infection With Mycobacterium ulcerans

Frontiers in Microbiology, 2020
Buruli ulcer (BU) is a neglected, tropical infectious disease of the skin and the subcutaneous tissue caused by Mycobacterium ulcerans. This pathogen has emerged as a new species from a common ancestor with Mycobacterium marinum by acquisition of the ...
Katharina Röltgen, Gerd Pluschke, Gerd Pluschke   +2 more
doaj   +1 more source

Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease. [PDF]

, 2014
BACKGROUND Buruli ulcer (BU) is a slowly progressing, necrotising disease of the skin caused by infection with Mycobacterium ulcerans. Non-ulcerative manifestations are nodules, plaques and oedema, which may progress to ulceration of large parts of ...
Miriam Bolz, Bolz, Miriam, Gerd Pluschke, Gert Zimmer, Meret E Ricklin, Marie-Thérèse Ruf, Ruf, Marie-Thérèse, Ricklin, Meret E, Ruggli, Nicolas, Zimmer, Gert, Ricklin, Meret E., Nicolas Ruggli, Pluschke, Gerd, Bolz Miriam, Ruggli Nicolas, Zimmer G, Bolz M, Zimmer Gert, Ruf MT, Ruggli N, Pluschke G, Ruf Marie-Thérèse, Pluschke Gerd, Ricklin ME, Ricklin Meret E.   +24 more
core   +3 more sources

Chronic cutaneous mycobacterial ulcers due to Mycobacterium ulcerans (Buruli ulcer): the first indigenous case report from Jordan and a literature review

International Journal of Infectious Diseases, 2017
Background: Buruli ulcer is the third most common mycobacterial infection worldwide. It is endemic in tropical, subtropical, and temperate climates. It causes devastating disease with morbidity and mortality.
Jamal Wadi Al Ramahi, Hassan Annab, Mutaz Al Karmi, Basel Kirresh, Mahmoud Wreikat, Rami Batarseh, Muhannad Yacoub, Mais Kaderi   +7 more
doaj   +1 more source