Results 91 to 100 of about 141,079 (249)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Identifying Infectious Agents in Snakes (Boidae and Pythonidae) with and Without Respiratory Disease

Animals
Mycoplasmas are known respiratory pathogens in tortoises, but few studies exist in snakes. To better understand the correlation with clinical signs and co-infections, samples from mycoplasma-positive snakes with and without clinical respiratory disease ...
Marline M. Faulhaber, Florence Tardy, Anne V. Gautier-Bouchardon, Sabine Öfner, Sebastiaan Theuns, Sieglinde Coppens, Elisabeth Müller, Michael Pees, Rachel E. Marschang   +8 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Remarkable Inhibition Efficacy of a Compound Plant Essential Oil Disinfectant Against Bacteria, Viruses, and Mycoplasmas

Veterinary Sciences
Infectious diseases caused by pathogenic microorganisms have caused serious economic losses to animal husbandry, and the use of appropriate disinfectants is crucial for eliminating these pathogens.
Ming Guan, Tao-Ni Zhang, Cheng Lu, Jin-Xin Zhou, Ri-Wang Yang, Xuan-Ming Dong, Cheng-Yu Zhang, Qi Wang, Wen-Qing Zhao, Yu Zhang, Tian-Chao Wei, Jian-Ni Huang, Teng Huang, Mei-Lan Mo   +13 more
doaj   +1 more source

Mycoplasma Pneumonia [PDF]

Annual Review of Medicine, 1966
B R, Forsyth, R M, Chanock
openaire   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Independent Predictors of Mycoplasma pneumoniae Infection: A Retrospective Cohort Study Among Hospitalized Adults in an East Texas Health Facility

Journal of Respiration
Background: Community-acquired pneumonia in the United States accounts for over five million cases annually, with an estimated one million hospitalizations.
Menkeoma Laura Okoli, Ibuchim Chinemerem Okoli, Abuoma Chisom Okoli, Ikechukwu Umezurike, Celestine Ishiekwene   +4 more
doaj   +1 more source

Mycoplasma Viruses

Intervirology, 1982
J, Maniloff, K, Haberer, R N, Gourlay, J, Das, R, Cole   +4 more
openaire   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source