Results 81 to 90 of about 89,623 (336)

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Respiratory mycoplasmosis in pediatrician's practice

Медицинский совет, 2016
Respiratory mycoplasmosis is a group of infectious and inflammatory diseases of the respiratory system caused by pathogenic microorganisms - Mycoplasma species. It was found that the major causative agent is Mycoplasma pneumoniae (M. pneumoniae).
A. L. Zaplatnikov, I. D. Maikova, I. V. Lepiseva   +2 more
doaj   +1 more source

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

Advanced Science, EarlyView.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang, Linyu Han, Yanfei Huo, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang   +6 more
wiley   +1 more source

Epidemiological study of hemotropic mycoplasmas (hemoplasmas) in cats from central Spain

Parasites & Vectors, 2018
Background Hemotropic mycoplasmas (hemoplasmas) have been found infecting cats worldwide. However, studies about feline hemoplasma infections in Spain are scarce.
David Díaz-Regañón, Alejandra Villaescusa, Tania Ayllón, Fernando Rodríguez-Franco, Mercedes García-Sancho, Beatriz Agulla, Ángel Sainz   +6 more
doaj   +1 more source

Development of a novel clinical scoring system for on-farm diagnosis of bovine respiratory disease in pre-weaned dairy calves. [PDF]

, 2014
Several clinical scoring systems for diagnosis of bovine respiratory disease (BRD) in calves have been proposed. However, such systems were based on subjective judgment, rather than statistical methods, to weight scores.
Aly, Sharif S, Kass, Philip H, Lehenbauer, Terry W, Love, William J, Van Eenennaam, Alison L   +4 more
core   +2 more sources

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight [PDF]

, 2004
We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock
A. Schropp, Benjamin MM, Berent LM, Birkenheuer A, Brinson J, Brodey RS, C. Wojtczyk, Crowell JW, Davies BN, Donovan EF, Dunham CM, E. Thein, F. Meisner, G. Enders, G. Kemming, Gretillat S, H. Kisch-Wedel, Hartwig G, Hoskins JD, J.B. Messick, K. Messmer, K. Packert, Krakowka S, Lester SL, Messick JB, Pryor, S. Muenzing, Seneviratna P, Venable JH, W. Mueller, Walcott WW, West HJ, Wiggers CJ, Withrington PG, Wright IG, Zweifach BW   +35 more
core   +1 more source

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

Frequency and hematological alterations of different hemoplasma infections with retrovirusis co-infections in domestic cats from Brazil

Pesquisa Veterinária Brasileira
: Mycoplasma haemofelis is the agent of feline infectious anemia, although Candidatus M. haemominutum can also be associated. This study evaluated the frequency and hematological alterations caused by hemoplasma infections and co-infections with FeLV ...
Fernanda P. Firmino, Larissa C. Aquino, Tatiana G. Marçola, Marta V. Bittencourt, Concepta M. McManus, Giane R. Paludo   +5 more
doaj   +1 more source

Expansion of Comprehensive Screening of Male Sexually Transmitted Infection Clinic Attendees with \u3cem\u3eMycoplasma genitalium\u3c/em\u3e and \u3cem\u3eTrichomonas vaginalis\u3c/em\u3e Molecular Assessment: a Retrospective Analysis [PDF]

, 2017
Of 1,493 encounters of males at a sexually transmitted infection (STI) clinic in a community with a high prevalence of STI, Chlamydia trachomatis was detected in 8.7% and Neisseria gonorrhoeae was detected in 6.6%.
Gerritts, Joshua, Hamer, Deb, Jhansale, Sheila, Munson, Erik, Munson, Kimber L., Napierala, Maureen, Pantuso, Nicki, Schuknecht, Mary Kay, Steward, Aaron, Wenten, David   +9 more
core   +1 more source