Results 61 to 70 of about 5,659 (219)

Efficacy and safety of myectomy and radiofrequency septal ablation for treating hypertrophic obstructive cardiomyopathy

Open Heart
Background Novel treatments are needed for patients with severely symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Radiofrequency (RF) septal ablation has emerged as a promising technique for improving the left ventricular outflow tract (LVOT)
Larissa Ventura Ribeiro Bruscky, Bruno Pereira Valdigem, Edileide de Barros Correia, Paulo Chaccur, Andrea de Andrade Vilela, Antônio Tito Paladino Filho, Ibraim Pinto, Rui Fernando Ramos, Jorge Eduardo Assef   +8 more
doaj   +1 more source

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activity.
Rahul Sanwlani, Georgina H. Thompson, Kyle Bramich, Ching‐Seng Ang, Millie L. Trowbridge, Chris E. Duringer, Vlad Stolojan, Sean M. Davidson, Konstantinos Savvatis, John H. McVey, Suresh Mathivanan, Aled Clayton, Patrizia Camelliti   +12 more
wiley   +1 more source

Hypertrophic obstructive cardiomyopathy: Comparison of outcomes after myectomy or alcohol ablation adjusted by propensity score [PDF]

, 2005
ObjectiveIn November 1998, our center began offering alcohol ablation as an alternative to surgical myectomy for patients with hypertrophic obstructive cardiomyopathy.
Anthony Ralph-Edwards, Anna Woo, Leonard Schwartz, Woo, Anna, Jonathan L. Shapero, Harry Rakowski, McCrindle, Brian W., E. Douglas Wigle, Wigle, E. Douglas, William G. Williams, Rakowski, Harry, Ralph-Edwards, Anthony, Schwartz, Leonard, Shapero, Jonathan L., Williams, William G., Brian W. McCrindle   +15 more
core   +1 more source

Surgical Myectomy after Failed Ablation for Hypertrophic Obstructive Cardiomyopathy

The Thoracic & Cardiovascular Surgeon Reports, 2016
Background Hypertrophic cardiomyopathy is a genetic disease of the myocardial sarcolemma characterized by left ventricular hypertrophy. When obstruction to the left ventricular outflow tract is present and symptoms are refractory to medication, surgical ...
Ioannis Bougioukas, Uta Hoppe, Bernhard Danner, Friedrich A. Schoendube   +3 more
doaj   +1 more source

Current state of the art and future of myectomy [PDF]

Annals of Cardiothoracic Surgery, 2017
Surgical relief of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) requires more than septal myectomy. The procedure is currently the gold standard for all symptomatic HCM patients except those with comorbidities. The operation requires an individualized approach to restore the sophisticated functions of the left
Magdi H, Yacoub, Ahmed, Afifi, Hesham, Saad, Heba, Aguib, Ahmed, ElGuindy   +4 more
openaire   +2 more sources

Infective Endocarditis Diagnosed by Emergency Physicians Using Cardiac POCUS: A Case Series

Australasian Journal of Ultrasound in Medicine, Volume 29, Issue 3, August 2026.
ABSTRACT Introduction Emergency physicians (EPs) are acquiring ever‐increasing expertise in cardiac point‐of‐care ultrasound (POCUS). We compiled this case series to demonstrate current practice by EPs diagnosing infective endocarditis (IE) using POCUS.
Jonathan Henry, Mark Rugless, Claudiu Radeanu, Abrar Waliuddin, Kevin Phang, Allan Whitehead, Shanu Khader, David Henry, Darsim Haji   +8 more
wiley   +1 more source

Recurrent and Progressive CAVB After Alcohol Septal Ablation for HOCM: Bridging Therapy With a Semi‐Permanent Pacemaker

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT In patients undergoing alcohol septal ablation for hypertrophic obstructive cardiomyopathy, complete atrioventricular block can be delayed and recurrent. A semi‐permanent pacemaker serves as an effective bridging therapy, allowing for extended monitoring of conduction recovery and may spare selected patients from permanent device implantation.
Enyuan Zhang, Le He, Henan Zhang, Jing Xu, Fengmin Lu, Dongyan Wu, Yitong Yin, Wei Ma   +7 more
wiley   +1 more source

Septal myectomy remains the gold standard [PDF]

European Heart Journal, 2012
This editorial refers to ‘A contemporary European experience with surgical septal myectomy in hypertrophic cardiomyopathy’, by A. Iacovoni et al. , doi:10.1093/eurheartj/ehs064 Improvements in the understanding of the haemodynamic abnormalities and pathophysiology of obstructive hypertrophic cardiomyopathy (HCM), as well as advances in surgical ...
openaire   +2 more sources

Echocardiographic findings late after myectomy in hypertrophic obstructive cardiomyopathy [PDF]

, 2017
Postoperative echocardiograms of 50 patients undergoing myectomy for hypertrophic obstructive cardiomyopathy between 1965 and 1982 have been evaluated. In 21 patients a comparison with preoperative echocardiograms showed that postoperatively there was a ...
KRAYENBUEHL, H.P., TURINA, J., ROTHLIN, M., TURINA, M., JENNI, R.   +4 more
core  

Long-term outcomes of surgery for obstructive hypertrophic cardiomyopathy in a pediatric cohortCentral MessagePerspective

JTCVS Open, 2023
Background: Septal reduction therapy via septal myectomy or a modified Konno procedure is the mainstay of therapy for drug-refractory obstructive hypertrophic cardiomyopathy (HCM), although outcomes data on septal myectomy in pediatric patients are ...
Stephanie N. Nguyen, MD, Megan M. Chung, BA, Alice V. Vinogradsky, BA, Marc E. Richmond, MD, MS, Warren A. Zuckerman, MD, Andrew B. Goldstone, MD, PhD, Emile A. Bacha, MD   +6 more
doaj   +1 more source