Results 41 to 50 of about 184,937 (258)

A rare presentation of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) as acute hemorrhagic longitudinally extensive transverse myelitis

The Egyptian Journal of Radiology and Nuclear Medicine, 2023
Background Myelin oligodendrocyte glycoprotein antibody-associated disease is usually associated with optic neuritis, acute disseminated encephalomyelitis or transverse myelitis.
Aniket Nerlekar, Sharad Malvadkar, Dhairyasheel Patil, Bhagyashree Bhoir, Neha Shaikh, Jagdish Sambare   +5 more
doaj   +1 more source

Mature and Myelinating Oligodendrocytes Are Specifically Vulnerable to Mild Fluid Percussion Injury in Mice

Neurotrauma Reports, 2023
Myelin loss and oligodendrocyte death are well documented in patients with traumatic brain injury (TBI), as well as in experimental animal models after moderate-to-severe TBI.
Alexandra A. Adams, Teresa L. Wood, Haesun A. Kim   +2 more
doaj   +1 more source

Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein [PDF]

Proceedings of the National Academy of Sciences, 2003
Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal loss. The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type I transmembrane protein located at the ...
Breithaupt, C., Schubart, A., Zander, H., Skerra, A., Huber, R., Linington, C., Jacob, U.   +6 more
openaire   +4 more sources

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [PDF]

, 2012
B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process.
Mayer, Marie Cathrin, Meinl, Edgar, Marie Cathrin Mayer, Edgar Meinl, Meinl, E., Mayer, M.   +5 more
core   +1 more source

Frequency of New Silent MRI Lesions in Myelin Oligodendrocyte Glycoprotein Antibody Disease and Aquaporin-4 Antibody Neuromyelitis Optica Spectrum Disorder

JAMA Network Open, 2021
Key Points Question How common is silent T2 lesion activity in myelin oligodendrocyte glycoprotein antibody disease (MOGAD) and aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-NMOSD)?
V. Camera, Leah Holm-Mercer, Ali Asgar Hatim Ali, S. Messina, Tim Horvat, W. Kuker, M. Leite, Jacqueline A Palace   +7 more
semanticscholar   +1 more source

Differential expression and MAL-dependent targeting of the L-MAG and S-MAG isoforms to myelin membranes [PDF]

, 2003
Many degenerative diseases of the nervous system, including Multiple Sclerosis and peripheral neuropathies, are triggered by an impaired interaction between the axons and their surrounding myelin sheaths.
Erb, Michael
core   +1 more source

Serum Neurofilament Light and GFAP Are Associated With Disease Severity in Inflammatory Disorders With Aquaporin-4 or Myelin Oligodendrocyte Glycoprotein Antibodies

Frontiers in Immunology, 2021
Objective: To evaluate the potential of serum neurofilament light (sNfL) and serum glial fibrillary acidic protein (sGFAP) as disease biomarkers in neuromyelitis optica spectrum disorder (NMOSD) with aquaporin-4 antibody (AQP4-ab) or myelin ...
Xuechun Chang, Wenjuan Huang, Liang Wang, Jingzi ZhangBao, Lei Zhou, Chuanzhen Lu, Min Wang, Jian Yu, Haiqing Li, Yuxin Li, Chongbo Zhao, Jiahong Lu, C. Quan   +12 more
semanticscholar   +1 more source

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P, Baker, MD, Coffey Pete, Jackson, SJ, Gavin Giovannoni, Baker David, Samuel J. Jackson (468645), Zubair Ahmed (9352), Jackson Samuel J., Zubair Ahmed, Ahmed, Z, Mark D Baker, Pete Coffey (422262), David Baker, Samuel J Jackson, Gavin Giovannoni (125820), Giovannoni Gavin, Munro Peter, Ahmed Zubair, Pete Coffey, David Baker (11642), Peter Munro (479715), Peter Munro, Lidster Katie, Baker Mark D., Baker, D, Lidster, K, Mark D. Baker (146531), Katie Lidster, Munro, P, Katie Lidster (479714), Giovannoni, G   +31 more
core   +1 more source

Synthesis of antagonists of Myelin-associated glycoprotein (MAG) for conformational and SAR studies [PDF]

, 2004
Damage to the central nervous system (CNS) of higher vertebrates, including humans, often results in devastating and persistent functional deficits.
Gao, Gan-Pan
core   +1 more source

Pathogenesis of autoimmune demyelination: from multiple sclerosis to neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody‐associated disease

Clinical & Translational Immunology, 2021
Autoimmunity plays a significant role in the pathogenesis of demyelination. Multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) are now recognised as ...
Joseph A Lopez, Martina Denkova, S. Ramanathan, R. Dale, F. Brilot   +4 more
semanticscholar   +1 more source