Results 31 to 40 of about 184,937 (258)

A Molecular Model of Myelin Oligodendrocyte Glycoprotein [PDF]

Journal of Neurochemistry, 1998
Abstract: Myelin oligodendrocyte glycoprotein (MOG) is a protein on the surface of myelin sheaths. It is a putative target of the autoimmune attack in the inflammatory and demyelinating CNS disease multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis.
P, Hjelmström, J E, Penzotti, R M, Henne, T P, Lybrand   +3 more
openaire   +2 more sources

Pathology of myelin oligodendrocyte glycoprotein antibody-associated disease: a comparison with multiple sclerosis and aquaporin 4 antibody-positive neuromyelitis optica spectrum disorders

Frontiers in Neurology, 2023
Myelin oligodendrocyte glycoprotein (MOG) is expressed on the outermost layer of the myelin sheath in the central nervous system. Recently, the clinical concept of MOG antibody-associated disease (MOGAD) was established based on the results of human MOG ...
Y. Takai, T. Misu, K. Fujihara, M. Aoki
semanticscholar   +1 more source

Measles–rubella vaccine–associated MOG-antibody positive acute demyelinating encephalomyelitis with optic neuritis in a child

Therapeutic Advances in Vaccines and Immunotherapy, 2022
Measles–rubella (MR) vaccine–associated encephalopathy is rare and coexistence with optic neuritis (ON) has never been reported. Only two patients (one child and one adult) had ‘MR Vaccine–associated myelin-oligodendrocyte-glycoprotein antibody (MOGAb ...
Madhumati Otiv, Abhijeet Botre, Pawan Shah   +2 more
doaj   +1 more source

Development of a novel model of optic neuritis to assess neuroprotective and repair strategies in multiple sclerosis [PDF]

, 2012
PhDMultiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS), which often affects the optic nerve pathway. Optic neuritis (ON) is a clinical feature of MS that can cause loss of vision due to conduction block and ...
Lidster, Katie
core   +4 more sources

Factors Associated With Relapse and Treatment of Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease in the United Kingdom

JAMA Network Open, 2022
This cohort study investigates factors associated with long-term risk of relapse among patients with myelin oligodendrocyte glycoprotein antibody–associated disease in the United Kingdom.
Chanjira Satukijchai, R. Mariano, S. Messina, M. Sa, M. Woodhall, N. Robertson, L. Ming, E. Wassmer, R. Kneen, S. Huda, A. Jacob, C. Blain, C. Halfpenny, C. Hemingway, Eoin O'sullivan, J. Hobart, L. Fisniku, Roswell J. Martin, Ruth Dopson, Sarah A Cooper, Victoria Williams, P. Waters, S. Ramdas, M. Leite, Jacqueline Palace   +24 more
semanticscholar   +1 more source

Association of Maintenance Intravenous Immunoglobulin With Prevention of Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

JAMA Neurology, 2022
Importance Recent studies suggest that maintenance intravenous immunoglobulin (IVIG) may be an effective treatment to prevent relapses in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); however, most of these studies had ...
John Chen, S. Huda, Y. Hacohen, M. Levy, I. Lotan, Adi Wilf-Yarkoni, H. Stiebel-Kalish, M. Hellmann, E. Sotirchos, A. D. Henderson, S. Pittock, M. Bhatti, E. Eggenberger, Marie A. Di Nome, H. Kim, Su-Hyun Kim, A. Saiz, Friedemann Paul, R. Dale, S. Ramanathan, Jacqueline Palace, V. Camera, M. Leite, B. Lam, J. Bennett, S. Mariotto, D. Hodge, B. Audoin, E. Maillart, R. Deschamps, J. Pique, E. Flanagan, R. Marignier   +32 more
semanticscholar   +1 more source

Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing

JAMA Neurology, 2021
Key Points Question What is the positive predictive value of myelin oligodendrocyte glycoprotein (MOG)–IgG1 testing in a clinical setting? Findings Of 1260 consecutive patients tested for MOG-IgG1 at the Mayo Clinic over 2 years, 92 (7.3%) were positive,
Elia Sechi, Marina Buciuc, S. Pittock, John J. Chen, J. Fryer, Sarah M. Jenkins, A. Budhram, B. Weinshenker, A. Lopez-Chiriboga, J. Tillema, A. McKeon, J. Mills, W. Tobin, E. Flanagan   +13 more
semanticscholar   +1 more source

Cerebral Cortical Encephalitis in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Neurology, 2022
Cerebral cortical encephalitis (CCE) is a recently described myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) phenotype. In this observational retrospective study, we characterized 19 CCE patients (6.7% of our MOGAD cohort ...
Cristina Valencia-Sanchez, Yong Guo, K. Krecke, John Chen, Vyanka Redenbaugh, Mayra Montalvo, P. Elsbernd, J. Tillema, Sebastian A. Lopez-Chiriboga, A. Budhram, Elia Sechi, Amy C. Kunchok, D. Dubey, S. Pittock, C. Lucchinetti, E. Flanagan   +15 more
semanticscholar   +1 more source

Invasive Multimodality Neuromonitoring to Manage Cerebral Edema in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Critical Care Explorations, 2023
Background:. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory disorder of the CNS with a variety of clinical manifestations, including cerebral edema. Case Summary:.
Nina A. Fainberg, MD, Maya R. Silver, MD, John D. Arena, MD, Elizabeth I. Landzberg, MD, Brenda Banwell, MD, Claudia Gambrah-Lyles, MD, Matthew P. Kirschen, MD, PhD, Peter J. Madsen, MD, Loren McLendon, MD, Sona Narula, MD, Alexander M. Tucker, MD, Jimmy W. Huh, MD, Martha F. Kienzle, MD   +12 more
doaj   +1 more source

Analysis of probable predictors of aggressive multiple sclerosis

Бюллетень сибирской медицины, 2020
Objective: to study the probable laboratory predictors of aggressive multiple sclerosis.Materials and methods. Antibodies to myelin oligodendrocyte glycoprotein (MOG), antibodies to thyroperoxidase and markers of endothelial dysfunction in blood serum ...
N. N. Spirin, E. V. Kiseleva, N. N. Spirina   +2 more
doaj   +1 more source