Results 81 to 90 of about 184,937 (258)

High Immunogenicity of Intracellular Myelin Oligodendrocyte Glycoprotein Epitopes [PDF]

The Journal of Immunology, 2002
Abstract Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the CNS with associated axonal loss. There is strong evidence for an autoimmune pathogenesis driven by myelin-specific T cells. Myelin oligodendrocyte glycoprotein (MOG) induces a type of experimental autoimmune encephalomyelitis in animals which is very ...
Robert, Weissert, Jens, Kuhle, Katrien L, de Graaf, Wolfgang, Wienhold, Martin M, Herrmann, Claudia, Müller, Thomas G, Forsthuber, Karl-Heinz, Wiesmüller, Arthur, Melms   +8 more
openaire   +2 more sources

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update

, 2022
Myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated optic neuritis has been established as a new entity of immune-mediated optic neuropathy. Patients usually present with recurrent optic neuritis, often bilaterally with initially severe
Vanessa Daccach Marques (5645420), Katharina Messias (5765279), Andre Messias (198395)   +2 more
core   +1 more source

Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

Journal of Neuroinflammation, 2020
New-generation cell-based assays have demonstrated a robust association of serum autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis, and brainstem encephalitis, as well as ...
S. Jarius, Hannah L. Pellkofer, N. Siebert, M. Korporal-Kuhnke, M. Hümmert, M. Ringelstein, Paulus S. Rommer, I. Ayzenberg, K. Ruprecht, L. Klotz, N. Asgari, Tobias Zrzavy, R. Höftberger, Rafik Tobia, M. Buttmann, K. Fechner, Kathrin Schanda, Martin S. Weber, Susanna Asseyer, J. Haas, C. Lechner, I. Kleiter, O. Aktas, C. Trebst, K. Rostásy, M. Reindl, T. Kümpfel, F. Paul, B. Wildemann   +28 more
semanticscholar   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Molecular mechanisms underlying Mash1 function in oligodendrogenesis [PDF]

, 2010
Members of the basic helix-loop-helix (bHLH) proneural family of proteins, including Mash1, are crucial transcription factors (TFs) in neurogenesis. More recently, a role for Mash1 in the specification of oligodendrocyte precursor cells (OPCs) has been ...
Galiñanes García, L.
core  

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update

, 2023
Myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated optic neuritis has been established as a new entity of immune-mediated optic neuropathy. Patients usually present with recurrent optic neuritis, often bilaterally with initially severe
Vanessa Daccach Marques (5645420), Katharina Messias (5765279), Andre Messias (198395)   +2 more
core   +1 more source

Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report

BMC Neurology, 2022
Background Serum antibodies to myelin-oligodendrocyte glycoprotein (MOG) are biomarkers of MOG-IgG-associated disorder (MOGAD), a demyelinating disease distinct from both multiple sclerosis and aquaporin-4-IgG neuromyelitis optica spectrum disorder.
Jan Kolcava, Aneta Rajdova, Eva Vlckova, Pavel Stourac, Josef Bednarik   +4 more
doaj   +1 more source

Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody

JAMA Neurology, 2019
Importance Recognizing the characteristics of myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) myelitis is essential for early accurate diagnosis and treatment.
D. Dubey, S. Pittock, Karl N. Krecke, P. Morris, Elia Sechi, Nicholas L. Zalewski, B. Weinshenker, Eslam Shosha, C. Lucchinetti, James P. Fryer, A. Lopez-Chiriboga, John Chen, J. Jitprapaikulsan, A. McKeon, A. Gadoth, B. M. Keegan, J. Tillema, E. Naddaf, M. Patterson, K. Messacar, Kenneth L. Tyler, E. Flanagan   +21 more
semanticscholar   +1 more source

E.U. paediatric MOG consortium consensus: Part 1 - Classification of clinical phenotypes of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders.

European journal of paediatric neurology, 2020
Over the past few years, increasing interest in the role of autoantibodies against myelin oligodendrocyte glycoprotein (MOG-abs) as a new candidate biomarker in demyelinating central nervous system diseases has arisen.
A. Bruijstens, C. Lechner, Lorraine Flet-Berliac, K. Deiva, R. Neuteboom, C. Hemingway, E. Wassmer   +6 more
semanticscholar   +1 more source

Acute urinary retention as first sign of myelin oligodendrocyte glycoprotein antibody disease (MOGAD) - Case report and literature review

Urology Case Reports
Myelin oligodendrocyte glycoprotein antibody disease is a rare, demyelinating condition of the central nervous system. We report a case of a male presenting with acute urinary retention and brainstem lesion, highlighting an atypical initial manifestation
Mariana Dias Capinha, Andreia Cardoso, Catarina Tinoco, Ana Sofia Araújo, Luís Pinto, Aparício Coutinho, Emanuel Dias, Miguel Mendes   +7 more
doaj   +1 more source