Results 151 to 160 of about 170,216 (297)

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

Enhancing Oligodendrogenesis Rescues Chronic Stress-Induced Behavioral Disorders Involving Neuronal and Synaptic Reorganization. [PDF]

Glia
Dai YP, Xu CL, Luo H, Liu ZY, Meng GX, Li JL, Yu AC, Chen X, Gao X, Zhang X, Wang JL, Chen T, Xiao L, Wang F, Mei F, Lei QJ, Li T.   +16 more
europepmc   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Myelin basic protein charge isomers change macrophage polarization

, 2019
Elene Tsitsilashvili,1 Maia Sepashvili,1,2 Marika Chikviladze,1 Lali Shanshiashvili,1,2,* David Mikeladze1,2,* 1Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia; 2Department of Biochemistry, I.
Chikviladze M, Tsitsilashvili E, Mikeladze D, Sepashvili M, Shanshiashvili L   +4 more
core  

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

The Maintenance of Dysmyelinated Small-Diameter Axons by 14-3-3s in the Central Nervous System. [PDF]

Glia
Yamada N, Saito H, Takahashi R, Fujisato M, Hosoda Y, Sasaki B, Yamada M, Abe S, Hayashi C, Yoshimoto A, Ohkawa R, Matt TJ, M Bareyre F, Berghoff S, Simons M, Suzuki N.   +15 more
europepmc   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Myelination sustains axonal bioenergetics by storing and consuming oxygen for aerobic metabolism. [PDF]

Proc Natl Acad Sci U S A
Panfoli I, Candiano G, Bruschi M.
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Reply to Panfoli et al.: From O₂ consumption in myelin to gap junctional ATP delivery in axons: An energy link needing further scrutiny. [PDF]

Proc Natl Acad Sci U S A
Witschas K, Ghysels A, Leybaert L.
europepmc   +1 more source