Results 181 to 190 of about 128,023 (218)

CDC42-Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity. [PDF]

Glia
Hümmert S, de Faria JP, Jahn O, Bilgin E, Łukasik N, Rao C, Mitkovski M, Benseler F, Brose N, Siems SB, Goebbels S, Möbius W, Ewers H, Relvas JB, Werner HB.   +14 more
europepmc   +1 more source

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

In vivo mapping of cortical amyloid beta-myelin coupling in preclinical Alzheimer's disease. [PDF]

Alzheimers Dement
Atienza M, Cantero JL.
europepmc   +1 more source

Impact of empiric potassium supplementation on mortality, sudden cardiac arrest and stroke in furosemide initiators

British Journal of Clinical Pharmacology, EarlyView.
Aim A prior non‐randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health‐care data to confirm or refute these associations among new users of ...
Thanh Phuong Pham Nguyen, Sean Hennessy, Colleen M. Brensinger, Warren B. Bilker, Laura M. Dember, Todd A. Miano, Tat‐Thang Vo, Allison W. Willis, Charles E. Leonard   +8 more
wiley   +1 more source

Raman and SERS Spectra of Human Myelin Basic Protein in Cerebrospinal Fluid. [PDF]

Nanomaterials (Basel)
Bravo-Oro A, Ugarte-Anchondo S, Martínez-Ruiz EO, Rodríguez-Aranda MDC, Reyes-Reyes A, García-Mendoza CI, Ortiz-Dosal LC, Rivera-Pérez E, Reyes-Reyes JA, Kolosovas-Machuca ES, Ortiz-Dosal A.   +10 more
europepmc   +1 more source

Cannabinoid CB₁ receptors drive oligodendrocyte maturation during myelin regeneration. [PDF]

Cell Commun Signal
Ezquerro-Herce S, Sánchez-de la Torre A, Monory K, Lutz B, Guzmán M, Aguado T, Palazuelos J.   +6 more
europepmc   +1 more source

Assessing Age-Associated Influences on Paramagnetic and Diamagnetic Susceptibility Maps in Postmortem Human Brains. [PDF]

NMR Biomed
de Azevedo JHM, Garcia Otaduy MC, Avanzine A, Diehl Rodriguez R, Seiji Otsuka F, Barbosa F, Liu C, Garrido Salmon CE.   +7 more
europepmc   +1 more source

Exploration of structure–activity relationship of 2,4‐diaminopyrimidine derivatives as hematopoietic progenitor kinase 1 inhibitors

Bulletin of the Korean Chemical Society, EarlyView.
Targeting HPK1 is a promising strategy to restore T‐cell anti‐tumor immunity. We report the design and synthesis of novel 2,4‐diaminopyrimidine derivatives, focusing on systematic structure–activity relationship (SAR) analysis These findings identify key structural features for potent HPK1 inhibition, facilitating the discovery of next‐generation ...
Heechan Shin, Mi‐Ran Byun, Joon Seok Choi, Sujin Lee   +3 more
wiley   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Resolving the mechanical paradox of myelination. [PDF]

Commun Biol
Fritzsche M.
europepmc   +1 more source