Results 221 to 230 of about 300,317 (388)

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

HISTOCHEMISTRY OF MYELIN. III. PERIPHERAL NERVE CATHEPSIN

, 1961
C. W. M. Adams, O. B. Bayliss
openalex   +1 more source

Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis

Advanced Science, EarlyView.
This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu, Xuyu Zhao, Zixin Chen, Jingying Huang, Tengteng Dai, Jianxin Zhou, Luyao Xiao, Luonan Chen, Robert Chunhua Zhao, Jiao Wang   +9 more
wiley   +1 more source

Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder. [PDF]

Mol Autism
Hanson KL, Avino T, Taylor SL, Murray KD, Schumann CM.   +4 more
europepmc   +1 more source

Immunocytochemical localization studies of myelin basic protein. [PDF]

, 1978
Jerry R. Mendell, John N. Whitaker
openalex   +1 more source

Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury

Advanced Science, EarlyView.
This study demonstrates that combining Ce0.7Zr0.3O2 nanozymes with nimodipine enhances neuroprotection after traumatic brain injury. The therapy reduces oxidative stress, neuronal apoptosis, and improves blood–brain barrier integrity, with nanozymes effective at low doses.
Xinjie Hong, Liang Zhao, Xianzheng Sang, Chao Ma, Meiqi Chang, Xinran Song, Wei Feng, Tao Xu, Li Ding, Yu Chen, Lijun Hou   +10 more
wiley   +1 more source

Prospero-related homeobox protein 1 (Prox1) enhances myelin sheath regeneration in injured sciatic nerve. [PDF]

IBRO Neurosci Rep
Jie L, Jing X, Liu J, Ren J, Kong X, Wu J, Meng F.   +6 more
europepmc   +1 more source

Labelling of egg phosphatidylcholine vesicles and myelin membrane with a photoreactive lipophilic reagent [PDF]

, 1977
Khalid M. Abu–Salah, J. B. C. Findlay
openalex   +1 more source

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

Advanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang, Qingyu Zhao, Qingfeng Zhang, Xiaofeng Wu, Xu Liu, Shujuan Wu, Hailing Liu, Beini Zhou, Shiqian Zha, Dong Zhao, Gang Deng, Ke Hu   +11 more
wiley   +1 more source

Spironolactone Targets Retinoid X Receptor γ to Promote Myelin Sheath Regeneration. [PDF]

Neurol Neuroimmunol Neuroinflamm
Sun QQ, Ai RS, Chai NN, Han B, Bao MY, Li YB, Ma GX, Wang LJ, Qian ZQ, Li X, Zhang Y.   +10 more
europepmc   +1 more source