Results 241 to 250 of about 133,930 (295)

Delayed Neuropsychiatric Syndrome Due to Unrecognized Carbon Monoxide Toxicity: A Case Report

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction Carbon monoxide (CO) is a leading cause of poison‐related deaths in children and frequently results in nonspecific neurological symptoms and imaging findings. Rarely, pediatric patients develop a delayed neuropsychiatric syndrome (DNS) following a lucid interval.
Alexandria Valdrighi   +3 more
wiley   +1 more source

Age-related changes in myelin and myelin water quantified with short-TR adiabatic inversion-recovery (STAIR) sequences. [PDF]

open access: yesNeuroimage Clin
Lo J   +9 more
europepmc   +1 more source

Clinically Important Endpoints in Individuals With Leukodystrophy: A Multisite Study

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Importance Leukodystrophies are a diverse group of rare disorders that disrupt central myelination. These disorders present with a broad spectrum of neurological severity and are associated with a range of potential secondary complications, such as scoliosis and failure of independent feeding.
Emma R. Kotes   +31 more
wiley   +1 more source

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann   +6 more
wiley   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano   +8 more
wiley   +1 more source

OMIP‐116: A 39‐Color Full Spectrum Flow Cytometric Panel to Deeply Characterize Human Thymopoiesis

open access: yesCytometry Part A, EarlyView.
ABSTRACT We report the development of a 39‐color (43‐parameter) full spectrum flow cytometry panel designed and optimized to deeply characterize the intrathymic development of human conventional and unconventional T cells. The panel was designed using strategies dictated by best practices for full spectrum and multiparametric flow cytometry, and was ...
Simone Balin   +6 more
wiley   +1 more source

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