Results 241 to 250 of about 300,317 (388)

Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury

open access: yesNature Neuroscience, 2019
Tian Zhou   +19 more
semanticscholar   +1 more source

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

open access: yesAdvanced Science, EarlyView.
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi   +18 more
wiley   +1 more source

Enhancing Spatial Transcriptomics via Spatially Constrained Matrix Decomposition with EDGES

open access: yesAdvanced Science, EarlyView.
Imaging‐based spatial transcriptomics technologies are currently limited by their restricted gene detection capacity and low measurement accuracy. Moreover, the insufficient integration of spatial context and single‐cell reference data poses a significant challenge for comprehensive data analysis.
Jinyue Zhao   +5 more
wiley   +1 more source

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements. [PDF]

open access: yesNat Commun
Levy G   +23 more
europepmc   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

open access: yesAdvanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha   +12 more
wiley   +1 more source

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