Results 291 to 300 of about 300,317 (388)

Demyelinated lesion associated compartmental inflammation in progressive multiple sclerosis brains. [PDF]

Acta Neuropathol Commun
Najm L, Chomyk A, Cyncynatus K, Davalos D, Mahajan KR, Trapp BD.   +5 more
europepmc   +1 more source

TSH Ligand‐Based CAR‐T Cell Effectively Eradicates TSHR‐Positive Thyroid Cancer with Favorable Safety Profile

Advanced Science, EarlyView.
TSHR is highly expressed in differentiated thyroid cancer (DTC), making it an ideal target for adoptive immune cell therapy. A novel Ligand‐based TSH‐CAR‐T cell approach effectively eradicated TSHR‐positive thyroid tumors in vitro and accomplished full remission in tumor models with favorable safety profile, highlighting that TSH‐CAR‐T cells could ...
Fei Wang, Hui Zuo, Li Liu, Shiyuan Wang, Haifang Zhao, Zhao Liu, Gang Wang, Zhao Liu, Junnian Zheng, Chuan Xu, Hongwei Du   +10 more
wiley   +1 more source

Wrap it up: myelination of transplanted neurons for repair. [PDF]

Front Cell Neurosci
Martínez-Reza MF, Götz M.
europepmc   +1 more source

Cross-linking studies on the conformation and dimerization of myelin basic protein in solution.

, 1978
E.E. Golds, Pascal Falter‐Braun
openalex   +1 more source

Neuroprotection and Axonal Regeneration via ECM‐Mimetic Nanofibers Incorporating Metal–Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair

Advanced Science, EarlyView.
Metal–phenolic network (MPN) nanoparticles with neuroprotective functions are integrated into decellularized extracellular matrix (dECM) to obtain biomimetic composite fibrous scaffold MPN@dECM NFs by electrospinning, which protects spared neurons from secondary degeneration by suppressing excitotoxicity and inflammation, and promotes directional ...
Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu, Xi Chen   +4 more
wiley   +1 more source

Combination therapy dramatically promotes remyelination. [PDF]

J Mol Cell Biol
Li Y, Li P, Song Y, Zhang W, Jiang X, Chen S, Luo W, Ma C, Liu C, Niu J, Liang A, Du Y, Zhou BO, Zhang M.   +13 more
europepmc   +1 more source

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

Advanced Science, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang, Yanling He, Pin Yang, Hengchang Zhang, Yueyang Tong, Lingling Jiang, Zehan Li, Meichen Yan, Xiaoheng Li, Qinghu Yang, Jing Yang, Zengqiang Yuan, Jiyan Zhang, Jinbo Cheng   +13 more
wiley   +1 more source

White Matter in Crisis: Oligodendrocytes and the Pathophysiology of Multiple Sclerosis. [PDF]

Cells
García-Domínguez M.
europepmc   +1 more source

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, EarlyView.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Adsorption of Myelin Basic Protein on Model Myelin Membranes Reveals Weakening of van der Waals Interactions in a Lipid Ratio-Dependent Manner. [PDF]

Membranes (Basel)
Maleš P, Pem B, Petrov D, Mangiarotti A, Dimova R, Bakarić D.   +5 more
europepmc   +1 more source