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Myelination and Retarded Myelination
1989Flechsig (1920) was the originator of the view that the degree of myelination of the central nervous system might be correlated with functional capacity. In his theory he stated that myelination started in projection pathways before association pathways, in peripheral nerves before central pathways, and in sensory areas before motor ones.
Marjo S. van der Knaap, Jacob Valk
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Biology of oligodendrocyte and myelin in the mammalian central nervous system.
Physiological Reviews, 2001Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and astrocytes constitute macroglia. This review deals with the recent progress related to the origin and differentiation of the oligodendrocytes, their relationships to ...
N. Baumann, D. Pham-Dinh
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Myelin, myelin-related disorders, and psychosis
Schizophrenia Research, 2015The neuropathological basis of schizophrenia and related psychoses remains elusive despite intensive scientific investigation. Symptoms of psychosis have been reported in a number of conditions where normal myelin development is interrupted. The nature, location, and timing of white matter pathology seem to be key factors in the development of ...
Michelle I. Mighdoll +3 more
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Current Opinion in Neurobiology, 1993
Myelin formation and maintenance requires complex interactions between neurons and glia, and between the integral protein and lipid components of the myelin sheath. Many of the underlying mechanisms may be examined by studying the perturbations caused by spontaneous and targeted mutations in myelin protein genes.
Ueli Suter +5 more
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Myelin formation and maintenance requires complex interactions between neurons and glia, and between the integral protein and lipid components of the myelin sheath. Many of the underlying mechanisms may be examined by studying the perturbations caused by spontaneous and targeted mutations in myelin protein genes.
Ueli Suter +5 more
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Morphological Aspects of Myelin and Myelination [PDF]
, 1977 Myelin is a membrane characteristic of the vertebrate nervous system, laid down in segments along selected nerve fibers, functioning as an insulator to increase the velocity of stimuli being transmitted between a nerve cell body and its target. Myelin is morphologically unique, and, while the present section will highlight this uniqueness, it is ...
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The enzymology of myelination [PDF]
Molecular and Cellular Biochemistry, 1973 We have presented a resume of recent investigations of the biochemistry of glycolipids and glycoproteins in the developing nervous system. The novel observations and advances in these areas coupled with relevant studies on the metabolism of myelin basic protein provide a basis for the development of a hypothesis regarding the formation of the myelin ...
Richard H. Quarles, Roscoe O. Brady
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Morphology of Myelin and Myelination
1984Myelin is a membrane characteristic of nervous tissue, laid down in segments along selected nerve fibers, that functions as an insulator to increase the velocity of stimuli being transmitted between a nerve-cell body and its target. While well documented in several invertebrates (annelids and crustaceans) in which it exists in its peripheral nervous ...
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Myelinated Nerve Fibre, Myelin
2010Nerve fibres designed for particularly rapid and efficient conduction of action potentials are equipped with a myelin sheath, a lipid-enriched layer, produced by specialised glial cells, the oligodendrocytes in the central nervous system, and the Schwann cells in the peripheral nervous system.
Jürgen Roth, Margit Pavelka
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Advanced Functional Materials, 2018
The myelin sheath enables dramatic speed enhancement for signal propagation in nerves. In this work, myelinated nerve structure is experimentally and theoretically studied using synchrotron‐radiation‐based Fourier‐transform infrared microspectroscopy. It
Guozhi Liu +9 more
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The myelin sheath enables dramatic speed enhancement for signal propagation in nerves. In this work, myelinated nerve structure is experimentally and theoretically studied using synchrotron‐radiation‐based Fourier‐transform infrared microspectroscopy. It
Guozhi Liu +9 more
semanticscholar +1 more source
Current Protocols in Cell Biology, 2006
AbstractThe methods used to prepare myelin involve homogenization of the tissue in isotonic sucrose solution, followed by the isolation of myelin membranes by a series of steps that include density gradient centrifugation and differential centrifugation. Homogenization of nervous tissue in isotonic sucrose causes the myelin sheath to peel from the axon
Williams T. Norton, Jorge N. Larocca
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AbstractThe methods used to prepare myelin involve homogenization of the tissue in isotonic sucrose solution, followed by the isolation of myelin membranes by a series of steps that include density gradient centrifugation and differential centrifugation. Homogenization of nervous tissue in isotonic sucrose causes the myelin sheath to peel from the axon
Williams T. Norton, Jorge N. Larocca
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