Results 111 to 120 of about 5,959 (257)

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Citrullinated isomer of myelin basic protein can induce inflammatory responses in astrocytes

IBRO Neuroscience Reports
Purpose: During the course of demyelinating inflammatory diseases, myelin-derived proteins, including myelin basic protein(MBP), are secreted into extracellular space.
Marika Chikviladze, Nino Mamulashvili, Maia Sepashvili, Nana Narmania, Jeremy Ramsden, Lali Shanshiashvili, David Mikeladze   +6 more
doaj   +1 more source

The classic basic protein of myelin-conserved structural motifs and the dynamic molecular barcode involved in membrane adhesion, protein–protein interactions, and pathogenesis in multiple sclerosis

, 2013
The myelin basic protein (MBP) family comprises a variety of developmentally-regulated members arising from different transcription start sites, differential splicing, and post-translational modifications.
D. S. Libich, POLVERINI, Eugenia, K. Vassall, G. Harauz   +3 more
core   +1 more source

Fish Scales: A Multifunctional Biomaterial from Nature

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Fish scales demonstrate nature's solution to impact protection through overlapping multilayered architecture. This biological design combines mineralized surfaces with collagen networks to achieve both flexibility and fracture resistance. The structural principles inspire advanced protective materials and biomedical implants, where damage tolerance ...
Liyao Dong, Xiaojie Sun, Xiguang Chen
wiley   +1 more source

Amyloid fibrils of the myelin basic protein are an integral component of myelin in the vertebrate brain

Scientific Reports
The myelin basic protein (MBP) is the most abundant intracellular protein of the myelin, which forms the electrically insulating sheath of axons of many actively functioning neurons. This protein binds the opposite membranes of the flattened processes of
Evgeniy I. Sysoev, Aleksandr A. Shenfeld, Tatyana A. Belashova, Anna A. Valina, Sergey P. Zadorsky, Alexey P. Galkin   +5 more
doaj   +1 more source

Nanoformulated Recombinant Human Myelin Basic Protein and Rituximab Modulate Neuronal Perturbations in Experimental Autoimmune Encephalomyelitis in Mice

International Journal of Nanomedicine, 2022
Muhammed A Saad,1,2 Noha M Eissa,2 Mohammed A Ahmed,3 Aliaa N ElMeshad,3,4 Götz Laible,5– 7 Ahmed S Attia,8 Medhat A Al-Ghobashy,9,10 Rania M Abdelsalam,1,2 Muhammad Y Al-Shorbagy1,11 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo
Saad MA, Eissa NM, Ahmed MA, ElMeshad AN, Laible G, Attia AS, Al-Ghobashy MA, Abdelsalam RM, Al-Shorbagy MY   +8 more
doaj  

The Influence of the Myelin Basic Protein C8 Mutant on the Dynamics of Myelin Membranes

, 2013
The dynamics of reconstituted myelin membranes were studied by$ackslash$nincoherent neutron scattering when the myelin basic protein was added.$ackslash$nThe mutant C8 has properties similar to the highly modified form seen in$ackslash$nMultiple ...
Peters, Judith, Gerelli, Yuri, Natali, Francesca, Knoll, Wiebke, Kursula, Petri   +4 more
core   +1 more source

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

Epilepsia, EarlyView.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin, Hui‐Min Huang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

Generation of MBP-tdTomato reporter human induced pluripotent stem cell line for live myelin visualization

Stem Cell Research
Myelin basic protein (MBP) is a major component of the myelin sheaths of oligodendrocytes in the central nervous system and Schwann cells of the peripheral nervous system.
Daigo Takagi, Satomi Tsukamoto, Koji Nakade, Tomoya Shimizu, Yutaka Arai, Mami Matsuo-Takasaki, Michiya Noguchi, Yukio Nakamura, Norihiro Yumoto, Jiro Kawada, Tadayoshi Hayata, Yohei Hayashi   +11 more
doaj   +1 more source

Conformation of bovine myelin basic protein purified with bound lipids

, 1999
The basic protein of myelin (called MBP) is an extrinsic protein of the myelin membrane. Its structure and function are still unknown. MBP has been extensively studied in its water-soluble form, but it is also known in a detergent-soluble form, which is ...
CAVATORTA, Paolo, F. ZITO, POLVERINI, Eugenia, A. FASANO, P. RICCIO   +4 more
core   +1 more source