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Myelin Basic Protein and Demyelinating Diseases
CRC Critical Reviews in Clinical Laboratory Sciences, 1986Myelin basic protein (MBP) is a major protein component of myelin sheath. Primarily because of its ability to induce experimental allergic encephalomyelitis (EAE) in animals, this protein has been considered to play an important role in the pathogenesis of multiple sclerosis (MS), which is one of the most common demyelinating diseases.
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1995
Myelin basic protein is a structural protein of the nervous system composed of three structural units joined by double phenylalanine residues. The central unit of this stucture — the B fragment — can be found free within the CSF in cases of demyelination or cerebral damage.
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Myelin basic protein is a structural protein of the nervous system composed of three structural units joined by double phenylalanine residues. The central unit of this stucture — the B fragment — can be found free within the CSF in cases of demyelination or cerebral damage.
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Is myelin basic protein crystallizable?
Neurochemical Research, 1992Myelin basic protein (MBP) is the predominant extrinsic protein in both central and peripheral nervous system myelins. It is thought to be involved in the stabilizing interactions between myelin membranes, and it may play an important role in demyelinating diseases such as multiple sclerosis.
J, Sedzik, D A, Kirschner
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Conformation of Myelin Basic Protein and Its Role in Myelin Formation
1978High resolution 13C and 1H NMR spectra of myelin basic protein over a range of pH and concentrations indicate that intramolecular folding of the polypeptide chain occurs in aqueous solution in the region of residues 85 to 116. At pH 4 in D2O solution, the 13C resonances due to nonprotonated carbons of phenylalanine and tryptophan are broadened and ...
B E, Chapman +2 more
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NMR studies on myelin basic protein
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983George L. Mendz +2 more
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Myelin basic protein peptides in urine
Annals of Neurology, 1992R, Barry, C, Bolton, P, Glynn, N, Groome
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